systemic sclerosis

a rare connective-tissue disease affecting many systems in the body, mainly in women (3-6:1) in their forties. Genetic and autoimmune factors may be implicated. Besides scleroderma, there may be involvement of the lungs, with pulmonary fibrosis; renal failure and gastrointestinal and myocardial disease also occur. See also CREST syndrome.

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see under scleroderma.

Medical dictionary. 2011.

Look at other dictionaries:

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