myeloid leukaemia

a variety of leukaemia in which the type of blood cell that proliferates abnormally originates in the blood-forming (myeloid) tissue of the bone marrow. Myeloid leukaemias may be acute or chronic and may involve any one of the cells produced by the marrow. Blood cells in patients with chronic myeloid leukaemia contain a reciprocal translocation between chromosomes 9 and 22, which leads to a foreshortened long arm of chromosome number 22 (this abnormal chromosome is called the Philadelphia chromosome). Molecular characterization of the translocation has led to the development of a specific drug to block the effects of this abnormality (STI571; see imatinib).

Medical dictionary. 2011.

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  • myeloid leukaemia — a variety of leukaemia in which the type of blood cell that proliferates abnormally originates in the blood forming (myeloid) tissue of the bone marrow. Myeloid leukaemias may be acute or chronic and may involve any one of the cells produced by… …   The new mediacal dictionary

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