tyrosine hydroxylase

tyrosine hydroxylase n an enzyme that catalyzes the first step in the biosynthesis of catecholamines (as dopamine and norepinephrine)

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ty·ro·sine hy·droxy·lase (TH) (tiґro-sēn hi-drokґsə-lās) a monooxygenase that activates molecular oxygen to catalyze the hydroxylation of tyrosine to dopa; it is found in adrenal medulla and catecholaminergic neurons and requires the cofactor tetrahydrobiopterin. Deficiency of the enzyme, an autosomal recessive trait caused by mutation of the TH gene, which encodes the enzyme, results in dopa-responsive dystonia. In official nomenclature, called tyrosine 3-monooxygenase [EC 1.14.16.2].

Medical dictionary. 2011.

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  • Tyrosine hydroxylase — or tyrosine 3 monooxygenase is the enzyme responsible for catalyzing the conversion of the amino acid L tyrosine to dihydroxyphenylalanine (DOPA). DOPA is a precursor for dopamine which in turn is a precursor for norepinephrine (noradrenaline)… …   Wikipedia

  • Tyrosine hydroxylase — La tyrosine hydroxylase est l enzyme qui catalyse la transformation de la tyrosine en L Dopa (DihydrOxyPhénylAlanine). La tyrosine hydroxylase catalyse la tyrosine en dihydroxyphenylalanine. Somm …   Wikipédia en Français

  • tyrosine hydroxylase — Enzyme required for the synthesis of the neurotransmitters noradrenaline and dopamine …   Dictionary of molecular biology

  • tyrosine hydroxylase — hī¦dräksəˌlās, āz noun ( s) Etymology: hydroxyl + ase : an enzyme that catalyzes the first step in the biosynthesis of catecholamines (as dopamine) …   Useful english dictionary

  • Tyrosine — L ou S( ) tyrosine D ou R(+) tyrosine …   Wikipédia en Français

  • Tyrosine — NatOrganicBox name=( S ) 2 Amino 3 (4 hydroxyphenyl) propanoic acid PubChem = 1153 CAS = 60 18 4 SMILES = N [C@@H] (Cc1ccc(O)cc1)C(O)=O C=9 | H=11 | N=1 | O=3 mass=181.19 g/molTyrosine (abbreviated as Tyr or Y) [cite web | author=IUPAC IUBMB… …   Wikipedia

  • (tyrosine 3-monooxygenase) kinase — In enzymology, a [tyrosine 3 monooxygenase] kinase (EC number|2.7.11.6) is an enzyme that catalyzes the chemical reaction:ATP + [tyrosine 3 monooxygenase] ightleftharpoons ADP + phospho [tyrosine 3 monooxygenase] Thus, the two substrates of this… …   Wikipedia

  • tyrosine 3-monooxygenase — ty·ro·sine 3 mono·oxy·ge·nase (tiґro sēn mon″o okґsə jən ās) [EC 1.14.16.2] official nomenclature for tyrosine hydroxylase …   Medical dictionary

  • Phenylalanine hydroxylase — predicted 3D structure of phenylalanine hydroxylase …   Wikipedia

  • Dopamine beta hydroxylase — (dopamine beta monooxygenase) Identifiers Symbols DBH; DBM External IDs …   Wikipedia

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