Shwartzman reaction

Shwartz·man reaction 'shwȯrts-mən-, 'shwärts- n either of two reactions resulting from administration of endotoxin to experimental animals and esp. rabbits:
a) a generalized reaction following two intravenous injections of endotoxin given 24 hours apart and marked by widespread hemorrhage, reduced numbers of white blood cells and platelets, renal necrosis, and death of the animal called also generalized Shwartzman reaction
b) a localized cutaneous reaction following subcutaneous injection of endotoxin followed 24 hours later by intravenous injection of endotoxin and marked by hemorrhage, necrosis, and white blood cell infiltration at the site of first injection called also Shwartzman phenomenon
Shwartzman Gregory (1896-1965)
American bacteriologist. Born in Odessa, Russia, Shwartzman received his medical degree in Brussels and later worked as a researcher at London's Lister Institute before coming to the U.S. in 1923. In 1926 he became head of the department of bacteriology at New York's Mount Sinai Hospital, where he spent the bulk of his career. Concurrently he held a professorship at Columbia University. His areas of research included immunological reactions in tissue cultures and the effects of vitamins on bacterial growth. In 1928 he published an article on the phenomenon of local skin reactivity to bacterial filtrates in which he described what is now known as the Shwartzman reaction or Shwartzman phenomenon.

Medical dictionary. 2011.

Look at other dictionaries:

  • Shwartzman reaction — Reaction that occurs when two injections of endotoxin are given to the same animal, particularly rabbits, 24h apart. In the local Shwartzman reaction the first injection is given intradermally, the second intravenously, and a haemorrhagic… …   Dictionary of molecular biology

  • Shwartzman reaction (phenomenon) — Shwartz·man reaction (phenomenon) (shwahrtsґmən) [Gregory Shwartzman, Russian bacteriologist in the United States, 1896–1965] see under reaction …   Medical dictionary

  • Shwartzman reaction generalized — a generalized reaction following two intravenous injections of endotoxin separated by 24 hours; it is characterized by widespread hemorrhages, bilateral cortical necrosis of the kidneys, and a marked fall in leukocyte and platelet counts and… …   Medical dictionary

  • Shwartzman reaction localized — a localized cutaneous reaction consisting of vascular necrosis, petechial hemorrhages, and leukocyte infiltration that occurs at the site of an original subcutaneous injection of endotoxin approximately 24 hours after an intravenous injection of… …   Medical dictionary

  • generalized Shwartzman reaction — n SHWARTZMAN REACTION (a) …   Medical dictionary

  • Réaction de Shwartzman — Classification et ressources externes DiseasesDB 31433 MeSH D012790 la réaction de Shwartzman, également connue sous le nom de Phénomène de Shwartzman, est une réaction (choc allergique ou endotoxique) rare d un org …   Wikipédia en Français

  • Shwartzman phenomenon — Infobox Disease Name = PAGENAME Caption = DiseasesDB = 31433 ICD10 = ICD9 = ICDO = OMIM = MedlinePlus = eMedicineSubj = eMedicineTopic = MeshID = D012790 Shwartzman phenomenon, also known as Shwartzman reaction, is a rare reaction of a body to… …   Wikipedia

  • reaction — 1. The response of a muscle or other living tissue or organism to a stimulus. 2. The color change effected in litmus and certain other organic pigments by contact with substances such as acids or alkalies; also the property that such substances… …   Medical dictionary

  • Shwartzman — Gregory, Russian bacteriologist in U.S., 1896–1965. See S. phenomenon, S. reaction, generalized S. phenomenon, Sanarelli S. phenomenon …   Medical dictionary

  • Shwartzman phenomenon — see under reaction …   Medical dictionary

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