rheumatoid factor

rheumatoid factor n an autoantibody of high molecular weight that reacts against immunoglobulins of the class IgG and is often present in rheumatoid arthritis

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(RF) antibodies directed against antigenic determinants, i.e., Gm, in the Fc region of the IgG class of immunoglobulins; these are found in the serum of about 80 per cent of persons with classical or definite rheumatoid arthritis, but only about 20 per cent of those with juvenile rheumatoid arthritis. Rheumatoid factors may be of the IgM, IgG, or IgA classes of immunoglobulins, although serologic tests measure only IgM. Rheumatoid factors also occur in other connective tissue diseases and infectious diseases, such as Sjцgren syndrome, systemic lupus erythematosus, sarcoidosis, subacute bacterial endocarditis, hepatitis A, and leprosy.

Medical dictionary. 2011.

Look at other dictionaries:

  • Rheumatoid factor — (RF or RhF) is an autoantibody (antibody direct against an organism s own tissues) most relevant in rheumatoid arthritis. It is an antibody against the Fc portion of IgG, which is itself an antibody. RF and IgG join to form immune complexes which …   Wikipedia

  • rheumatoid factor — n. an antibody usually found in the blood serum of people with rheumatoid arthritis …   English World dictionary

  • rheumatoid factor — rheumatoid factor. См. ревматоидный фактор. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • rheumatoid factor — Complex of IgG and anti IgG formed in joints in rheumatoid arthritis. Serum rheumatoid factors are more usually formed from IgM antibodies directed against IgG …   Dictionary of molecular biology

  • rheumatoid factor — noun Date: 1949 an autoantibody of high molecular weight that reacts against IgG immunoglobulins and is often present in rheumatoid arthritis …   New Collegiate Dictionary

  • rheumatoid factor — Biochem. an antibody that is found in the blood of many persons afflicted with rheumatoid arthritis and that reacts against globulins in the blood. [1945 50] * * * …   Universalium

  • rheumatoid factor — rheu′matoid fac tor n. pat biochem. an antibody that is found in the blood of many persons afflicted with rheumatoid arthritis and that reacts against globulins in the blood • Etymology: 1945–50 …   From formal English to slang

  • rheumatoid factor — noun autoantibody that is usually present in the serum of people with rheumatoid arthritis • Hypernyms: ↑autoantibody …   Useful english dictionary

  • Rheumatoid arthritis — Classification and external resources A hand affected by rheumatoid arthritis ICD 10 M …   Wikipedia

  • Factor, rheumatoid — Rheumatoid factor is an antibody that is measurable in the blood. It is commonly used as a blood test for the diagnosis of rheumatoid arthritis. Rheumatoid factor is present in about 80% of adults (but a much lower proportion of children) with… …   Medical dictionary

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