Paget's disease

Pag·et's disease .paj-əts- n
1) a rare form of breast cancer initially manifested as a scaly red rash on the nipple and areola
2) a chronic disease of bones characterized by their great enlargement and rarefaction with bowing of the long bones and deformation of the flat bones called also osteitis deformans, osteodystrophia deformans

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1. a chronic disease of bones, occurring in the elderly and most frequently affecting the skull, backbone, pelvis, and long bones. Affected bones become thickened and their structure disorganized: X-rays reveal patchy sclerosis. There are often no symptoms, but pain, deformity, and fracture can occur; when the skull is affected, blindness and deafness can occur due to nerve compression. There is a very small (1%) risk of malignant change (osteosarcoma). Treatment is with bisphosphonates or calcitonin. Medical name: osteitis deformans.
2. a malignant condition of the nipple, resembling eczema in appearance, associated with underlying infiltrating cancer of the breast. See also breast cancer.
3. an uncommon condition of the vulva characterized by an epithelial lesion that histologically resembles the lesion of Paget's disease of the nipple. It may be associated with locally invasive adenocarcinoma of the surrounding skin, as well as tumours at other sites.
Sir J. Paget (1814-99), British surgeon

Medical dictionary. 2011.

Look at other dictionaries:

  • Paget's disease — n. 1. a disease that deforms and weakens bones, in which rapid decalcification is followed by excessive calcification 2. a type of cancer usually involving the breast s larger ducts, areola, and nipple …   English World dictionary

  • Paget-Schroetter disease — Infobox Disease Name = Paget Schroetter disease Caption = Anterior view of right upper limb and thorax DiseasesDB = 34349 ICD10 = ICD10|I|82|8|i|80 ICD9 = ICD9|453.8 ICDO = OMIM = MedlinePlus = eMedicineSubj = med eMedicineTopic = 2772 MeshID =… …   Wikipedia

  • Paget's disease — Sir James Paget, a surgeon and pathologist, described several diseases, including: Paget s disease of bone (most common use of Paget s disease) Paget s disease of the breast Paget Schroetter disease Extramammary Paget s disease (EMPD) This… …   Wikipedia

  • Paget's disease — 1) a chronic disease of bones, occurring in the elderly and most frequently affecting the skull, backbone, pelvis, and long bones. Affected bones become thickened and their structure disorganized: X rays reveal patchy sclerosis. There are often… …   The new mediacal dictionary

  • Paget's disease — Pag′et s disease [[t]ˈpædʒ ɪts[/t]] n. 1) pat a disease characterized by episodic accelerated bone resorption and growth of abnormal replacement bone 2) pat an inflammatory condition of the nipple associated with breast cancer Etymology: 1875–80; …   From formal English to slang

  • Paget's disease — noun Etymology: Sir James Paget died 1899 English surgeon Date: 1880 1. a rare form of breast cancer initially manifested as a scaly red rash on the nipple and areola 2. a chronic disease in which the bones become enlarged, weak, and deformed …   New Collegiate Dictionary

  • Paget's disease — Pathol. a chronic disease characterized by episodic accelerated bone resorption and growth of abnormal replacement bone, causing bone pain, deformation, fractures, and osteosarcoma; osteitis deformans. [1875 80; named after Sir James PAGET, who… …   Universalium

  • Paget's disease — [ padʒɪts] noun 1》 a chronic disease of the elderly characterized by alteration of bone tissue, especially in the spine, skull, or pelvis. 2》 an inflammation of the nipple associated with breast cancer. Origin C19: named after the English surgeon …   English new terms dictionary

  • Paget's disease — noun The bone disease osteitis deformans. See Also: Pagets disease of the breast, Pagets disease of the penis …   Wiktionary

  • Paget's disease — /ˈpædʒəts dəziz/ (say pajuhts duhzeez) noun 1. a chronic disorder, osteitis deformans, in which the bones are enlarged, deformed, and weakened. 2. cancer of the breast, involving nipple and associated ducts. {named after Sir James Paget, 1814–99 …   Australian English dictionary

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