- light chain n either of the two smaller of the four polypeptide chains that are subunits of antibodies called also L chain compare HEAVY CHAIN
* * *any of the smaller polypeptide chains of antibody molecules, two identical light chains occurring (with two identical heavy chains) in each immunoglobulin monomer. There are two types, designated κ and λ, both occurring in all immunoglobulin classes (in a ratio of about two κ chains to one λ chain in humans). Light chains have two homology regions of about 110 amino acid residues: one variable region (VL) and one constant region (CL). Called also L c. See immunoglobulin.
Medical dictionary. 2011.
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Light chain — A light chain is the small polypeptide subunit of a protein complex such as a motor protein (e.g. myosin, kinesin, or dynein) or an antibody (or immunoglobulin).More specifically, it can refer to: * Immunoglobulin light chain * Ferritin light… … Wikipedia
light chain — noun : either of the two smaller of the four polypeptide chains that are subunits of antibodies compare heavy chain herein * * * Immunol. either of an identical pair of polypeptides in the antibody molecule that lie parallel to the upper parts of … Useful english dictionary
light chain — Immunol. either of an identical pair of polypeptides in the antibody molecule that lie parallel to the upper parts of the heavy chain pair and are half the molecular weight. Also called L chain. [1960 65] * * * … Universalium
light chain — noun Date: 1964 either of the two smaller of the four polypeptide chains comprising antibodies compare heavy chain … New Collegiate Dictionary
light chain — Nonspecific term used of the smaller subunits of several multimeric proteins, for example immunoglobulin, myosin, dynein, clathrin. See also L chain … Dictionary of molecular biology
light chain proteinuria — overflow proteinuria with increased light chain fragments of immunoglobulins, as in Fanconi syndrome … Medical dictionary
light chain deposition disease — abnormal deposition of light chains in multiple organs; the most prominent symptoms are caused by glomerular deposition, which causes renal insufficiency, proteinuria, and the nephrotic syndrome. In some patients it is associated with multiple… … Medical dictionary
light chain nephropathy — nephropathy caused by deposition of abnormal light chains (usually kappa chains but sometimes lambda chains) in renal basement membranes, often with glomerulosclerosis; it may be associated with a plasma cell dyscrasia such as multiple myeloma… … Medical dictionary
Myosin light-chain kinase — myosin light polypeptide kinase, smooth muscle Identifiers Symbol MYLK Entrez 4638 HUGO … Wikipedia
Immunoglobulin light chain — Schematic diagram of an typical antibody showing two Ig heavy chains (blue) linked by disulfide bonds to two Ig light chains (green). The constant (C) and variable (V) domains are shown … Wikipedia