One of a family of glycoproteins (carbohydrates complexed with proteins) that are made in cells, secreted by cells, and incorporated into cells including blood platelets (thrombocytes) from which they take their name. Five distinct forms have been identified; they are termed thrombospondin-1, thrombospondin-2, thrombospondin-3, thrombospondin-4, and thrombospondin-5. The thrombospondins are known to interact with blood coagulation and anticoagulant factors. They are involved in cell adhesion, platelet aggregation (clumping), cell proliferation (growth), angiogenesis (blood vessel formation), tumor metastasis, and tissue repair. Thrombospondin-1 and thrombospondin-2 have been shown to be potent inhibitors of angiogenesis and suppressors of tumor growth in laboratory mice. (Proc Natl Acad Sci USA 1999;96:14888-14893.)

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throm·bo·spon·din (throm″bo-sponґdin) a 450-kilodalton multifunctional glycoprotein secreted by endothelial cells and by the alpha granules of platelets following activation by thrombin; it interacts with a wide variety of molecules, including heparin, fibrin, fibrinogen, platelet cell membrane receptors, collagen, and fibronectin, and plays a role in platelet aggregation, tumor metastasis, adhesion of Plasmodium falciparum, vascular smooth muscle growth, and tissue repair in skeletal muscle following crush injury.

Medical dictionary. 2011.

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  • Thrombospondin 1 — The thrombospondin 1 (TSP1) protein is a member of the Thrombospondin family and is encoded by the gene THBS1. It is a multi domain matrix glycoprotein that has been shown to be a natural inhibitor of neovascularization and tumorigenesis in… …   Wikipedia

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  • Thrombospondin — Thrombospondins (TSP) are secreted proteins with antiangiogenic abilities. TypesThe thrombospondins (TSP) are a family of multifunctional proteins. The family consists of thrombospondins 1 5 and can be divided into 2 subgroups: A, which contains… …   Wikipedia

  • thrombospondin — Homotrimeric glycoprotein (450 kD) from a granules of platelets, and synthesized by various cell types in culture. Also found in extracellular matrix of cultured endothelial, smooth muscle, and fibroblastic cells. May have autocrine growth… …   Dictionary of molecular biology

  • thrombospondin — noun Any of a group of secreted glycoproteins with antiangiogenic properties See Also: thrombin …   Wiktionary

  • THBS — thrombospondin …   Medical dictionary

  • THBS — • thrombospondin …   Dictionary of medical acronyms & abbreviations

  • THBS2 — Thrombospondin 2, also known as THBS2, is a human gene.cite web | title = Entrez Gene: THBS2 thrombospondin 2| url = Cmd=ShowDetailView TermToSearch=7058| accessdate = ] PBB Summary section title …   Wikipedia

  • THBS4 — Thrombospondin 4, also known as THBS4, is a human gene.cite web | title = Entrez Gene: THBS4 thrombospondin 4| url = Cmd=ShowDetailView TermToSearch=7060| accessdate = ] PBB Summary section title …   Wikipedia

  • THBS3 — Thrombospondin 3, also known as THBS3, is a human gene.cite web | title = Entrez Gene: THBS3 thrombospondin 3| url = Cmd=ShowDetailView TermToSearch=7059| accessdate = ] PBB Summary section title …   Wikipedia

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