- clumping), cell proliferation (growth), angiogenesis (blood vessel formation), tumor metastasis, and tissue repair. Thrombospondin-1 and thrombospondin-2 have been shown to be potent inhibitors of angiogenesis and suppressors of tumor growth in laboratory mice. (Proc Natl Acad Sci USA 1999;96:14888-14893.)
* * *throm·bo·spon·din (throm″bo-sponґdin) a 450-kilodalton multifunctional glycoprotein secreted by endothelial cells and by the alpha granules of platelets following activation by thrombin; it interacts with a wide variety of molecules, including heparin, fibrin, fibrinogen, platelet cell membrane receptors, collagen, and fibronectin, and plays a role in platelet aggregation, tumor metastasis, adhesion of Plasmodium falciparum, vascular smooth muscle growth, and tissue repair in skeletal muscle following crush injury.
Medical dictionary. 2011.
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Thrombospondin 1 — The thrombospondin 1 (TSP1) protein is a member of the Thrombospondin family and is encoded by the gene THBS1. It is a multi domain matrix glycoprotein that has been shown to be a natural inhibitor of neovascularization and tumorigenesis in… … Wikipedia
Thrombospondin — Thrombospondine (TSP) sind sezernierte Proteine, die das Wachstum von kleinen Blutgefäßen (Angiogenese) hemmen. Bedeutung Die Thrombospondine sind eine Familie von Proteinen, die an unterschiedlichen biologischen Prozessen beteiligt sind. Aus… … Deutsch Wikipedia
Thrombospondin — Thrombospondins (TSP) are secreted proteins with antiangiogenic abilities. TypesThe thrombospondins (TSP) are a family of multifunctional proteins. The family consists of thrombospondins 1 5 and can be divided into 2 subgroups: A, which contains… … Wikipedia
thrombospondin — Homotrimeric glycoprotein (450 kD) from a granules of platelets, and synthesized by various cell types in culture. Also found in extracellular matrix of cultured endothelial, smooth muscle, and fibroblastic cells. May have autocrine growth… … Dictionary of molecular biology
thrombospondin — noun Any of a group of secreted glycoproteins with antiangiogenic properties See Also: thrombin … Wiktionary
THBS — thrombospondin … Medical dictionary
THBS — • thrombospondin … Dictionary of medical acronyms & abbreviations
THBS2 — Thrombospondin 2, also known as THBS2, is a human gene.cite web | title = Entrez Gene: THBS2 thrombospondin 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=7058| accessdate = ] PBB Summary section title … Wikipedia
THBS4 — Thrombospondin 4, also known as THBS4, is a human gene.cite web | title = Entrez Gene: THBS4 thrombospondin 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=7060| accessdate = ] PBB Summary section title … Wikipedia
THBS3 — Thrombospondin 3, also known as THBS3, is a human gene.cite web | title = Entrez Gene: THBS3 thrombospondin 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=7059| accessdate = ] PBB Summary section title … Wikipedia