experimental allergic encephalomyelitis
- experimental allergic encephalomyelitis n an inflammatory autoimmune disease that has been induced in laboratory animals and esp. mice by injecting them with diseased tissue from affected animals or with myelin basic protein and that because of the similarity of its pathology to multiple sclerosis in humans is used as an animal model in studying this condition abbr. EAE called also experimental autoimmune encephalomyelitis
* * *(EAE) an animal model for acute disseminated encephalomyelitis in which the characteristic pathophysiology and clinical signs of this disease are produced by immunization of an animal with extracts of brain tissue or with myelin basic protein together with Freund adjuvant; it is transferable by adoptive transfer of lymphocytes but not by serum.
Medical dictionary. 2011.
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