creatine kinase

creatine kinase n any of three isoenzymes found esp. in vertebrate skeletal and myocardial muscle and the brain that catalyze the transfer of a high-energy phosphate group from phosphocreatine to ADP with the formation of ATP and creatine and typically occur in elevated levels in the blood following injury to brain or muscle tissue

* * *

an enzyme involved in the metabolic breakdown of creatine to creatinine. Isomers of creatine kinase originate from brain and thyroid (BB), skeletal muscle (MM), and cardiac muscle (MB). Any damage to these tissues causes an increase of the isomer in the serum, which can be used in diagnosis, particularly of myocardial infarction.

* * *

cre·a·tine ki·nase (CK) (kreґə-tin kiґnās) [EC 2.7.3.2] an Mg2+-activated enzyme of the transferase class that catalyzes the phosphorylation of creatine by ATP to form phosphocreatine. The reaction effectively stores the energy of ATP as phosphocreatine in muscle and brain tissue and holds the muscle concentration of ATP nearly constant during the initiation of exercise. It occurs as three isoenzymes, each having two components composed of M (muscle) and of B (brain) subunits. CK1 (BB) is found primarily in brain, CK2 (MB) primarily in cardiac muscle, and CK3 (MM) primarily in skeletal muscle. Differential determination of isoenzymes is useful for clinical diagnoses.

Medical dictionary. 2011.

Look at other dictionaries:

  • Creatine kinase — Créatine kinase Créatine kinase Cristaux de créatine kinase Général Synonymes EC …   Wikipédia en Français

  • Créatine kinase — Cristaux de créatine kinase Général Synonymes EC …   Wikipédia en Français

  • Créatine kinase — ● Créatine kinase enzyme essentiellement musculaire intervenant dans la mise en réserve d énergie par phosphorylation de la créatine …   Encyclopédie Universelle

  • creatine kinase — creatine kinase. См. креатинкиназа. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • Creatine kinase — Crystals of creatine kinase Creatine kinase (CK), also known as creatine phosphokinase (CPK) or phospho creatine kinase (and sometimes incorrectly as creatinine kinase), is an enzyme (EC 2.7.3.2) expressed by various tissues and cell types. CK… …   Wikipedia

  • creatine kinase — (= creatine phosphokinase) (EC 2.7.3.2.) Dimeric enzyme (82 kD) that catalyses the formation of ATP from ADP and creatine phosphate in muscle …   Dictionary of molecular biology

  • creatine kinase — noun Date: 1964 any of three isoenzymes found especially in vertebrate skeletal and myocardial muscle that catalyze the transfer of a high energy phosphate group from phosphocreatine to ADP with the formation of ATP and creatine …   New Collegiate Dictionary

  • creatine kinase — noun An enzyme that catalyzes the phosphorylation of creatine …   Wiktionary

  • creatine kinase — noun : any of three isoenzymes found especially in vertebrate skeletal and myocardial muscle and the brain that catalyze the transfer of a high energy phosphate group from phosphocreatine to ADP with the formation of ATP and creatine and… …   Useful english dictionary

  • creatine kinase — Biochem. an enzyme that, during muscular activity, catalyzes the transfer of a phosphoryl group from phosphocreatine in muscle to produce ATP. * * * …   Universalium

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.