Syndecan

One of a family of core proteins with sugars attached to the cell surfaces that control or influence tissue repair, metabolism, the formation of tumors and the development of immune responses. The name is derived from the Greek syndein, to bind together. There are 4 known members of the syndecan family. All are proteoglycans (molecules composed of protein and glycosaminoglycans, a type of polysaccharide). The syndecans are ubiquitous components of the plasma membranes of cells, act as receptors for the extracellular matrix, and are involved in intracellular communication. The gene SDC1 for syndecan-1 is on chromosome 2p24.1. The gene SDC2 for syndecan-2 is on chromosome 8q22-q24. The gene SDC3 for syndecan-3 has not yet been mapped to a specific chromosome location. The gene SDC4 for syndecan-4 is on chromosome 20q12-q13.

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syn·de·can (sinґdə-kan) any of a group of integral membrane proteoglycans, consisting of a 33-kD core and a variable number of heparan sulfate and chondroitin sulfate chains; the extracellular domain binds a number of proteins of the extracellular matrix, and syndecans have roles in both cell signaling and cell adhesion.

Medical dictionary. 2011.

Look at other dictionaries:

  • Syndecan 1 — is a proteoglycan. PBB Summary section title = summary text = The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell… …   Wikipedia

  • syndecan — An integral membrane proteoglycan (250 300 kD) associated largely with epithelial cells. The core protein of 294 amino acids has an extracellular domain of 235 amino acids and a single transmembrane domain of 25 amino acids. The extracellular… …   Dictionary of molecular biology

  • syndecan — noun Any of a class of single transmembrane domain proteins thought to act as coreceptors, especially for G protein coupled receptors …   Wiktionary

  • SDC3 — Syndecan 3, also known as SDC3, is a human gene.cite web | title = Entrez Gene: SDC3 syndecan 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=9672| accessdate = ] PBB Summary section title = summary text …   Wikipedia

  • SDC2 — Syndecan 2, also known as SDC2, is a human gene. PBB Summary section title = summary text = The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The… …   Wikipedia

  • SDC4 — Syndecan 4, also known as SDC4, is a human gene. PBB Summary section title = summary text = The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan that functions as a receptor in intracellular signaling. The… …   Wikipedia

  • SDCBP — Syndecan binding protein (syntenin), also known as SDCBP, is a human gene. PBB Summary section title = summary text = The protein encoded by this gene was initially identified as a molecule linking syndecan mediated signaling to the cytoskeleton …   Wikipedia

  • SDCBP2 — Syndecan binding protein (syntenin) 2, also known as SDCBP2, is a human gene.cite web | title = Entrez Gene: SDCBP2 syndecan binding protein (syntenin) 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView… …   Wikipedia

  • Sindecán-4 — Este artículo o sección tiene un estilo difícil de entender para lectores que no son expertos en el tema. Si puedes, por favor edítalo y contribuye a hacerlo más accesible para el público general, sin eliminar los detalles técnicos que interesan… …   Wikipedia Español

  • Lacritin — Lacritin, also known as LACRT, is a protein which in humans is encoded by the LACRT gene.cite web | title = Entrez Gene: LACRT lacritin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=90070| accessdate = ]… …   Wikipedia

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