- alkylating agent n a substance that causes replacement of hydrogen by an alkyl group esp. in a biologically important molecule specif one with mutagenic activity that inhibits cell division and growth and is used to treat some cancers
* * *a highly reactive compound that can substitute alkyl groups for the hydrogen atoms of certain organic compounds. Such agents are cytotoxic, producing their effects by the scission and cross-linking of DNA chains, and are not cell cycleâ€“specific, but cell killing occurs primarily in rapidly proliferating tissues in which there is not time between mitoses for DNA repair systems to reverse the effects of the agent. Classes of antineoplastic alkylating agents include nitrogen mustards, ethylenimine derivatives, alkyl sulfonates, nitrosoureas, triazenes, and platinum compounds. Hematopoietic, reproductive, and epithelial tissues are particularly sensitive to alkylating agents, and their use may cause depressed blood cell counts, amenorrhea or impaired spermatogenesis, damage to intestinal mucosa, alopecia, and increased risk of malignancy.
Medical dictionary. 2011.
Look at other dictionaries:
alkylating agent — alkylating agent. См. алкилирующий агент. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) … Молекулярная биология и генетика. Толковый словарь.
alkylating agent — A reagent that places an alkyl group, eg. propyl in place of a nucleophilic group in a molecule. Alkylating reagents include a number of cytotoxic drugs some of which react fairly specifically with N7 of the purine ring and lead to depurination… … Dictionary of molecular biology
alkylating agent — noun Date: 1900 a substance that causes replacement of hydrogen by an alkyl group especially in a biologically important molecule; specifically one with mutagenic activity that inhibits cell division and growth and is used to treat some cancers … New Collegiate Dictionary
alkylating agent — A class of chemicals that transfer alkyl (methyl, ethyl, etc.) groups; for example to the bases in DNA. Some of these (especially ethyl methane sulphonate, abbreviated EMS) have been much used as mutagens … Glossary of Biotechnology
alkylating agent — A drug that is used in the treatment of cancer. It interferes with the cell s DNA and inhibits cancer cell growth … English dictionary of cancer terms
alkylating agent — noun an antineoplastic drug used to treat some forms of cancer • Hypernyms: ↑antineoplastic, ↑antineoplastic drug, ↑cancer drug • Hyponyms: ↑chlorambucil, ↑Leukeran * * * noun : a substance that causes replacement of hyd … Useful english dictionary
Alkylating antineoplastic agent — An alkylating antineoplastic agent is an alkylating agent that attaches an alkyl group to DNA.Since cancer cells generally proliferate unrestrictively more than healthy cells do, cancer cells are more sensitive to DNA damage such as being… … Wikipedia
agent — 1. An active force or substance capable of producing an effect. For agents not listed here, see the specific name. 2. A disease, a factor such as a microorganism, chemical substance, or a form of radiation the presence or … Medical dictionary
Antiarrhythmic agent — The cardiac action potential Antiarrhythmic agents are a group of pharmaceuticals that are used to suppress abnormal rhythms of the heart (cardiac arrhythmias), such as atrial fibrillation, atrial flutter, ventricular tachycardia, and ventricular … Wikipedia
Hypolipidemic agent — Hypolipidemic agents, or antihyperlipidemic agents, are a diverse group of pharmaceuticals that are used in the treatment of hyperlipidemias. They are called lipid lowering drugs (LLD) or agents. Contents 1 Classes of hypolipidemic drugs 1.1… … Wikipedia