Somatic mutation

A change in a gene or chromosome that occurs in a general body cell, as opposed to a germ cell, and so cannot be transmitted to children. A somatic mutation occurs in a single cell after the conception of the individual. That change is then transmitted to all cells descended from that cell, giving rise to a clone of cells marked by the mutation. Some somatic mutations are involved in the development of cancer. For example, colon cancer occurs because of a somatic mutation in the cells lining the inner colon. Somatic mutations are also termed acquired mutations.

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somatic mutation n a mutation occurring in a somatic cell and inducing a chimera

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a mutation in a somatic cell, rather than a germ cell; it provides the basis for mosaicism, but is not transmitted to progeny. Somatic mutations have been implicated in the development of many forms of cancer. Cf. germline m.

Medical dictionary. 2011.

Look at other dictionaries:

  • somatic mutation — Mutation that occurs in the somatic tissues of an organism, and that will not, therefore, be heritable, since it is not present in the germ cells. Some neoplasia is due to somatic mutation; a more conspicuous example is the reversion of some… …   Dictionary of molecular biology

  • somatic mutation — somatic mutation. См. соматическая мутация. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • somatic mutation — noun : change originating in a somatic cell due to chance loss of genes or to genic change and constituting the cause of chimera formation * * * somatic mutation noun A mutation occurring in somatic cells, and therefore not inheritable • • • Main …   Useful english dictionary

  • somatic mutation — somatinė mutacija statusas T sritis augalininkystė apibrėžtis Mutacija, vykstanti somatinėse ląstelėse. atitikmenys: angl. somatic mutation rus. соматическая мутация …   Žemės ūkio augalų selekcijos ir sėklininkystės terminų žodynas

  • somatic mutation — Mutation in any cell other than a germ cell or its precursor …   Dictionary of invertebrate zoology

  • somatic mutation — An alteration in DNA that occurs after conception. Somatic mutations can occur in any of the cells of the body except the germ cells (sperm and egg) and therefore are not passed on to children. These alterations can (but do not always) cause… …   English dictionary of cancer terms

  • Somatic evolution in cancer — Somatic evolution is the accumulation of mutations in the cells of a body (the soma) during a lifetime, and the effects of those mutations on the fitness of those cells. Somatic evolution is important in the process of aging as well as the… …   Wikipedia

  • Somatic hypermutation — (or SHM) is a mechanism inside cells that is part of the way the immune system adapts to the new foreign elements which confront it (for example, microbes). SHM diversifies the receptors that the immune system uses to recognize foreign elements… …   Wikipedia

  • Mutation — For other uses, see Mutation (disambiguation). Part of the Biology series on Evolution …   Wikipedia

  • Mutation, somatic — A change in a gene or chromosome that occurs in a general body cell, as opposed to a germ cell, and so cannot be transmitted to children. A somatic mutation occurs in a single cell after the conception of the individual. That change is then… …   Medical dictionary

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