Phosphatase, alkaline

An enzyme made in the liver, bone, and the placenta and normally present in high concentrations in growing bone and in bile. Alkaline phosphatase is released into the blood during injury and during such normal activities as bone growth and pregnancy. It is measured in a routine blood test. Abnormally high blood levels of alkaline phosphatase may indicate disease in bone or liver, bile duct obstruction, or certain malignancies. The enzyme is often elevated in the leukemic cells in chronic myelogenous leukemia. Abnormally low levels of alkaline phosphatase is a genetic condition called hypophosphatasia which results in bone deformities. The enzyme is termed alkaline phosphatase because it works under alkaline (non-acidic) conditions, as opposed to acid phosphatase.

Medical dictionary. 2011.

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  • Alkaline phosphatase — An enzyme made in the liver, bone, and the placenta and normally present in high concentrations in growing bone and in bile. Alkaline phosphatase is released into the blood during injury and during such normal activities as bone growth and… …   Medical dictionary

  • Alkaline phosphatase — (ALP) (EC number|3.1.3.1) is a hydrolase enzyme responsible for removing phosphate groups from many types of molecules, including nucleotides, proteins, and alkaloids. The process of removing the phosphate group is called dephosphorylation . As… …   Wikipedia

  • alkaline phosphatase — alkaline phosphatase. См. щелочная фосфатаза. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • phosphatase — Any of a group of enzymes (EC 3.1.3.x) that liberate orthophosphate from phosphoric esters. SEE ALSO: phosphohydrolases. acid p. a p. with an optimum pH of less than 7.0 (for several isozymes, it is 5.4), notably present in the prostate gland;… …   Medical dictionary

  • alkaline phosphatase — n. Biochem. a phosphatase active in an alkaline medium. [1945 50] * * * ▪ enzyme       enzyme that is normally present in high concentrations in growing bone and in bile. It is essential for the deposition of minerals in the bones and teeth.… …   Universalium

  • Phosphatase — A phosphatase is an enzyme that removes a phosphate group from its substrate by hydrolysing phosphoric acid monoesters into a phosphate ion and a molecule with a free hydroxyl group (see dephosphorylation). This action is directly opposite to… …   Wikipedia

  • alkaline phosphatase —    A phosphatase active in alkaline media …   Forensic science glossary

  • alkaline phosphatase — n. Biochem. a phosphatase active in an alkaline medium. [1945 50] …   Useful english dictionary

  • phosphatase — n. one of a group of enzymes capable of catalysing the hydrolysis of phosphoric acid esters. An example is glucose 6 phosphatase, which catalyses the hydrolysis of glucose 6 phosphate to glucose and phosphate. Phosphatases are important in the… …   The new mediacal dictionary

  • phosphatase — noun Date: 1912 an enzyme that accelerates the hydrolysis and synthesis of organic esters of phosphoric acid and the transfer of phosphate groups to other compounds: a. alkaline phosphatase b. acid phosphatase …   New Collegiate Dictionary

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