APLS (antiphospholipid antibody syndrome)


APLS (antiphospholipid antibody syndrome)
An immune disorder characterized by the presence of abnormal antibodies in the blood associated with abnormal blood clotting, migraine headaches, recurrent pregnancy losses (repeat spontaneous abortions), and low blood platelet counts (thrombocytopenia). The abnormal antibodies are directed against phospholipids, fats that contains phosphorous. APLS can occur by itself (primary APLS) or be caused by another underlying condition (secondary APLS). About a third of persons with primary APLS have heart valve abnormalities. Antiphospholipid antibodies reduce the levels of annexin V, a protein that binds phospholipids and has potent anticoagulant activity. The reduction of annexin V levels is thought to be a possible mechanism underlying the increased tendency of blood to clot and the propensity to pregnancy loss characteristic of the antiphospholipid antibody syndrome.

Medical dictionary. 2011.

Look at other dictionaries:

  • Antiphospholipid antibody syndrome (APLS) — An immune disorder characterized by the presence of abnormal antibodies in the blood associated with abnormal blood clotting, migraine headaches, recurrent pregnancy losses (repeat spontaneous abortions), and low blood platelet counts… …   Medical dictionary

  • Syndrome, antiphospholipid antibody — An immune disorder characterized by the presence of abnormal antibodies in the blood associated with abnormal blood clotting, migraine headaches, recurrent pregnancy losses (repeat spontaneous abortions), and low blood platelet counts… …   Medical dictionary

  • Antiphospholipid syndrome — Classification and external resources Micrograph showing an advanced thrombotic microangiopathy, as may be seen in ALPA syndrome. Kidney biopsy. PAS stain …   Wikipedia

  • Plasmapheresis — Pheresis redirects here. It is not to be confused with Phoresis. Plasmapheresis Intervention ICD 10 PCS 6A5 ICD 9 CM …   Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.