- * * *Excessive formation of dense trabecular bone and calcified cartilage, especially in long bones, leading to obliteration of marrow spaces and to anemia with myeloid metaplasia and hepatosplenomegaly beginning in infancy, to bone fragility, and to progressive deafness and blindness; autosomal dominant inheritance. There are also autosomal recessive forms, which may be mild [MIM*259710], severe [MIM*259700], or lethal [MIM*259720], and sometimes involve a renal tubular defect [MIM*259730]. A milder, autosomal dominant form has onset in childhood and no neurologic sequelae. SYN: Albers-Schönberg disease, marble bone disease, marble bones. [osteo- + G. petra, stone, + -osis, condition]
* * *os·teo·pe·tro·sis -pə-'trō-səs n, pl -tro·ses -.sēz a condition characterized by abnormal thickening and hardening of bone: asa) a rare hereditary disease characterized by extreme density and hardness and abnormal fragility of the bones with partial or complete obliteration of the marrow cavities called also Albers-Schönberg disease, marble bone disease, marble bonesb) avian leukosis of chickens marked by great enlargement and excessive calcification of the long bones esp. of the legs and by more or less complete obliteration of the marrow cavities called also marble bone, marble bone disease
* * *n.a congenital abnormality in which bones become abnormally dense and brittle and tend to fracture. Affected bones appear unusually opaque to X-rays. In severe forms the bone marrow is obliterated, causing anaemia and infections. Treatment is by bone marrow transplantation. See also osteosclerosis.
* * *os·teo·pe·tro·sis (os″te-o-pe-troґsis) [osteo- + Gr. petra stone + -osis] a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. It occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. In the recessive form, the proliferation of bone obliterates the marrow cavity, causing anemia and hepatosplenomegaly, and narrowing the foramina of the skull, causing compression of cranial nerves, which may result in deafness and blindness. Fractures are common in both forms. Called also Albers-SchÑ†nberg or marble bones disease, ivory bones, and marble bones.
Medical dictionary. 2011.
Look at other dictionaries:
Osteopetrosis — (Malignant) Classification and external resources X ray of the pelvis of a patient with osteopetrosis, adult onset form (Albers Schonberg disease). Note the dense bones. ICD … Wikipedia
Osteopetrosis — (Malignant) Clasificación y recursos externos CIE 10 Q78.2 CIE 9 756.52 OMIM … Wikipedia Español
osteopetrosis — f. patol. Enfermedad hereditaria generalmente autosómica recesiva que se caracteriza por una condensación anormalmente alta de los huesos. La osteopetrosis provoca una menor elasticidad de los huesos y por tanto una mayor tendencia a las… … Diccionario médico
osteopetrosis — osteopetrosis. См. болезнь Альберса Шенберга. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) … Молекулярная биология и генетика. Толковый словарь.
Osteopetrosis — Klassifikation nach ICD 10 Q78.2 Marmorknochenkrankheit … Deutsch Wikipedia
osteopetrosis — Eng. Osteopetrosis Ver enfermedad de Alberts Schonberg … Diccionario de oftalmología
osteopetrosis — The formation of abnormally dense bone, as opposed to osteoporosis … Dictionary of molecular biology
osteopetrosis — /os tee oh pi troh sis/, n. Pathol. any of several hereditary diseases characterized by increased bone density. [1925 30; OSTEO + Gk petro , var. s. of petroûn to turn to stone (deriv. of pétra stone) + sis SIS; see OSIS] * * * … Universalium
osteopetrosis — noun A rare hereditary disorder characterized by hard, dense bones. Syn: marble bone disease, Albers Schonberg disease … Wiktionary
osteopetrosis — n. condition characterized by hardening of the bones (Pathology) … English contemporary dictionary