- reading) of messenger RNA (mRNA) resulting in a polypeptide chain that ends prematurely and a protein product that is truncated (abbreviated) and incomplete and usually nonfunctional. The nonsense mutation converts a codon (a triplet of bases) that encodes an amino acid into a stop codon, one that specifies the termination of translation. There are three nonsense codons (UAG, UAA, and UGA) in mRNA. One of them comes normally at the end of each polypeptide. A nonsense codon is a stop codon which is out of place. Catching such a defective messenger RNA (mRNA) before a truncated and potentially harmful protein is synthesized is the job of what is called the nonsense-mediated mRNA decay (NMD) pathway.
* * *a mutation in which one of the three termination codons in the mRNA (UAG, amber; UAA, ochre; UGA, umber or opal), used to signal the end of a polypeptide, appears in the middle of a genetic message, causes premature termination of transcription, and results in the production of an incomplete, generally nonfunctional polypeptide. See also missense m.
Medical dictionary. 2011.
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nonsense mutation — nonsense mutation. См. нонсенс мутация. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) … Молекулярная биология и генетика. Толковый словарь.
Nonsense mutation — In genetics, a nonsense mutation is a point mutation in a sequence of DNA that results in a premature stop codon, or a nonsense codon in the transcribed mRNA, and in a truncated, incomplete, and usually nonfunctional protein product. It differs… … Wikipedia
nonsense mutation — beprasmė mutacija statusas T sritis augalininkystė apibrėžtis Genetinė mutacija, kurioje prasmingas kodonas pasidaro beprasmiškuoju ir atvirkščiai – beprasmiškasis kodonas pasidaro prasmingu kodonu. atitikmenys: angl. nonsense mutation rus.… … Žemės ūkio augalų selekcijos ir sėklininkystės terminų žodynas
nonsense mutation — Mutation in coding DNA that prevents the protein from being synthesized … Dictionary of molecular biology
nonsense mutation — A mutation that converts a sense codon to a nonsense or stop codon … Dictionary of microbiology
nonsense mutation — A mutation that changes a coding triplet into a triplet that codes for no amino acid and terminates the polypeptide chain … Dictionary of invertebrate zoology
nonsense mutation — noun A point mutation that generates either a premature stop codon, or a codon that does not specify any amino acid … Wiktionary
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Mutation — For other uses, see Mutation (disambiguation). Part of the Biology series on Evolution … Wikipedia