* * *an antibody produced artificially from a cell clone and therefore consisting of a single type of immunoglobulin. Monoclonal antibodies are produced by fusing antibody-forming lymphocytes from mouse spleen with mouse myeloma cells. The resulting hybrid cells multiply rapidly (like cancer cells) and produce the same antibody as their parent lymphocytes. Monoclonal antibodies can be used for treating some malignant tumours (e.g. brain tumours, breast cancer, lymphoma, and leukaemia), which can be targeted by these antibodies (known colloquially as 'magic bullets'). See also infliximab, rituximab, trastuzumab.
Medical dictionary. 2011.
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monoclonal antibody — n. Immunology an antibody produced by a hybridoma for a specific antigen … English World dictionary
monoclonal antibody — Biotech. antibody produced by a laboratory grown cell clone, either of a hybridoma or a virus transformed lymphocyte, that is more abundant and uniform than natural antibody and is able to bind specifically to a single site on almost any chosen… … Universalium
monoclonal antibody — (MAb; mon o klōn al) An antibody of a single type that is produced by a population of genetically identical plasma cells (a clone); a monoclonal antibody is typically produced from a cell culture derived from the fusion product of a cancer cell… … Dictionary of microbiology
monoclonal antibody — an antibody produced artificially from a cell clone and therefore consisting of a single type of immunoglobulin. Monoclonal antibodies are produced by fusing antibody forming lymphocytes from mouse spleen with mouse myeloma cells. The resulting… … The new mediacal dictionary
monoclonal antibody — noun any of a class of antibodies produced in the laboratory by a single clone of cells or a cell line and consisting of identical antibody molecules • Syn: ↑monoclonal • Hypernyms: ↑antibody • Hyponyms: ↑infliximab, ↑Remicade … Useful english dictionary
monoclonal antibody — A type of protein made in the laboratory that can locate and bind to substances in the body and on the surface of cancer cells. There are many kinds of monoclonal antibodies; each one is made to find a different substance. Monoclonal antibodies… … English dictionary of cancer terms
monoclonal antibody — noun an antibody produced by a single clone of cells or cell line and consisting of identical antibody molecules … English new terms dictionary
monoclonal antibody — mon′oclo′nal an′tibody n. lab any antibody produced by a laboratory grown cell clone, either of a hybridoma or a virus transformed lymphocyte, in order to achieve greater abundance and uniformity than provided by a natural antibody Abbr. MAb •… … From formal English to slang
monoclonal antibody — /ˌmɒnoʊkloʊnəl ˈæntibɒdi/ (say .monohklohnuhl anteebodee) noun an antibody produced by a cell cloned in a laboratory, which produces antibodies more abundantly and uniformly than a natural cell, the antibody being able to bind specifically to a… … Australian English dictionary
monoclonal antibody — Abbreviation: mAb An antibody, produced by a hybridoma, directed against a single antigenic determinant of an antigen … Glossary of Biotechnology