Marker

A piece of DNA that lies on a chromosome so close to a gene that the marker and the gene are inherited together. A marker is thus an identifiable heritable spot on a chromosome. A marker can be an expressed region of DNA (a gene) or a segment of DNA with no known coding function. All that matters is that the marker can be monitored.
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1. A device used to make a mark or to indicate measurement. 2. A characteristic or factor by which a cell or molecule can be recognized or identified. 3. A locus containing two or more alleles that, being harmless, are common and therefore yield high frequencies of heterozygotes which facilitate linkage analysis.
- allotypic m. SYN: allotype.
- cell m. an identifying characteristic of a cell; e.g., formation of rosettes with sheep erythrocytes as a m. of T lymphocytes, or the presence of surface immunoglobulin as a m. of B lymphocytes.
- cell surface m. a surface protein, glycoprotein, or group of proteins that distinguish a cell or subset of cells from another defined subset of cells.
- genetic m. SYN: genetic determinant.
- linkage m. a locus at which there is a high probability of heterozygotes (indispensible state for linkage analysis), but in itself perhaps of no clinical interest. SEE ALSO: m. locus.
- oncofetal m. a tumor m. produced by tumor tissue and by fetal tissue of the same type as the tumor, but not by normal adult tissue from which the tumor arises.
- polymorphic genetic m. inherited characteristic that occurs within a given population as two or more traits.
- time m. an instrument that marks the time, usually in seconds or fractions of seconds, on a kymograph record in physiologic experiments.
- tumor m. a substance, released into the circulation by tumor tissue, whose detection in the serum indicates the presence of tumor.

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mark·er 'mär-kər n something that serves to identify, predict, or characterize <a surface \marker on a cell that acts as an antigen>: as
a) biomarker
b) GENETIC MARKER called also marker gene

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mark·er (mahrkґər) something that identifies or that is used to identify; cf. determinant.

Medical dictionary. 2011.

Look at other dictionaries:

  • Marker — Marker …   Deutsch Wörterbuch

  • Marker — may refer to: Marker (linguistics), a morpheme that indicates some grammatical function Marker (telecommunications), a special purpose computer A set of sewing patterns tightly arranged within a rectangle that is placed over cloth to be cut… …   Wikipedia

  • Marker — bezeichnet einen farbigen Markierstift, um Textpassagen hervorzuheben, siehe Marker (Stift) eine biologische Substanz, die als Indikator auf einen biologischen Zustand hindeutet, siehe Biomarker eine körpereigene Substanz, die auf die Anwesenheit …   Deutsch Wikipedia

  • Märker — steht für: Berliner Burschenschaft der Märker Märker (Zeitung), ein Anzeigenblatt in vier Landkreisen von Nordbrandenburg Märker Gruppe, ein Zement und Umwelttechnik Konzern Der Märker, Landeskundliche Zeitschrift für den Bereich der ehemaligen… …   Deutsch Wikipedia

  • MARKER (C.) — MARKER CHRIS (1921 ) Écrivain et cinéaste français, né (selon certaines sources) à Paris, dans le quartier de Belleville. Sa formation première reste enveloppée d’obscurité. Journaliste après la guerre, il crée aux éditions du Seuil la collection …   Encyclopédie Universelle

  • marker — UK US /ˈmɑːkər/ noun ► [C] a sign that shows what something is like or proves that something exists: a marker of sth »The company sees its invitation to join the business forum as a marker of success. ► [C, usually singular] something that is… …   Financial and business terms

  • marker — [MÁR CĂR] s. m. 1. genă mutantă cu efecte fenotipice detectabile, cu localizare cunoscută, care permite localizarea altor gene. 2. particularitate morfologică ce permite identificarea corectă a unui cromozom. ♢ cromozom diferit de omologul său… …   Dicționar Român

  • marker — / mɑ:kə/, it. / marker/ s. ingl. [der. di (to ) mark segnare, contrassegnare ], usato in ital. al masch. [pennarello a punta grossa usato per marcare con inchiostro colorato singole parole o parti di un testo] ▶◀ ‖ evidenziatore …   Enciclopedia Italiana

  • marker — O.E. mearcere writer, notary (glossing L. notarius clerk ), lit. one who marks, agent noun from MARK (Cf. mark) (v). Not found again until late 15c., hence modern use is perhaps a separate formation. Meaning monument stone is from 1888. Meaning… …   Etymology dictionary

  • marker — màrkēr m <G markéra> DEFINICIJA 1. predmet koji služi kao znak (zastavica, kolčić) 2. onaj koji označuje što, stavlja oznaku na što; označitelj, bilježitelj 3. flomaster kojim se vuku debele crte tako da su lako uočljive i s veće daljine… …   Hrvatski jezični portal

  • marker — [mär′kər] n. a person or thing that marks; specif., a) a person who keeps score in a game b) a device for keeping score c) a device for marking lines, as on a tennis court d) a bookmark e) a gravestone ☆ f) a milestone or similar sign …   English World dictionary

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