Malignant giant cell tumor

: A type of bone tumor characterized by massive destruction of bone near the end (epiphysis) of a long bone. The site most commonly struck by this tumor is the knee — the far end of the femur and the near end of the tibia. The tumor is often coated by new bony growth. It causes pain and restricts movement. Treatment is by surgery, usually followed by chemotherapy. There is no evidence that the tumor cells themselves are capable of bone destruction; instead, the tumor cells stimulate the formation of cells that function like osteoclasts and resorb bone. The term "giant cell" reflects the fact that osteoclasts are large multinucleate cells (cells with more than one nucleus) that look gigantic when viewed magnified through a microscope. Malignant giant cell tumor, known also as giant cell tumor of bone, has been osteoclastoma, reflecting the long-held incorrect view that the tumor cells are themselves osteoclasts.

Medical dictionary. 2011.

Look at other dictionaries:

  • Giant-cell tumor of bone — Classification and external resources Micrograph of a giant cell tumor of bone showing the characteristic giant cells. H E stain …   Wikipedia

  • Giant cell tumor of bone — Giant cell tumor of the bone (also called giant cell myeloma or osteoclastoma) is a relatively uncommon tumor. It is characterized by the presence of multinucleated giant cells (osteoclast like cells). These tumors are generally benign.cite… …   Wikipedia

  • giant-cell tumor — n an osteolytic tumor affecting the metaphyses and epiphyses of long bones, composed of a stroma of spindle cells containing dispersed multinucleate giant cells, and usu. being benign but sometimes malignant called also osteoclastoma …   Medical dictionary

  • Giant cell tumor of bone — A tumor of bone characterized by massive destruction of the end (epiphysis) of a long bone. The site most commonly struck by this tumor is the knee the far end of the femur and the near end of the tibia. The tumor is often coated by new bony… …   Medical dictionary

  • giant cell tumor — a benign or malignant tumor containing giant cells; see under carcinoma, granuloma, and sarcoma …   Medical dictionary

  • giant cell sarcoma — a form of giant cell tumor of bone (q.v.) that arises malignant de novo, rather than transforming to malignancy. 2. sarcoma characterized by large anaplastic (giant) cells …   Medical dictionary

  • giant cell carcinoma — a poorly differentiated, highly malignant, epithelial neoplasm containing numerous very large, multinucleated tumor cells, such as occurs in the lungs …   Medical dictionary

  • tumor — 1. Any swelling or tumefaction. 2. SYN: neoplasm. 3. One of the four signs of inflammation (t., calor, dolor, rubor) enunciated by Celsus. [L. t., a swelling] acinar cell t. a …   Medical dictionary

  • Tumor — Neoplastic tumor of the cheek skin, here a benign neoplasm of the sweat glands called Hidradenoma, which is not solid but is fluid filled. A tumor or tumour is commonly used as a synonym for a neoplasm (a solid or fluid filled (cystic) lesion… …   Wikipedia

  • malignant fibrous histiocytoma — any of a group of malignant neoplasms found mainly in soft tissues in middle aged adults; depending on the tumor location and the classification system, the term is sometimes used synonymously with or as a general term including similar lesions… …   Medical dictionary

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.