uteroglobin

steroid-inducible, evolutionarily conserved, homodimeric secreted protein with many biological activities including a proinflammatory effect, inhibition of soluble lipoprotein-lipase A2, and chemotaxis of neutrophils and monocytes. It binds to several putative receptors on several cell types and inhibits cellular invasion of the extracellular matrix. It is found in blood and urine, uterus and numerous other tissues but not kidneys. In mice u. has been shown to bind to fibronectin (Fn), preventing Fn self-aggregation and subsequent abnormal tissue deposition, especially in glomeruli. It is essential for maintaining normal renal function in mice. SYN: bastokinin.

* * *

utero·glo·bin (uґtər-o-glo″bin) a globulin found in the uterine lumen of some mammals and in the blood and urine of humans; in mice it stimulates and regulates blastocyst implantation. Other biological activities, including antiinflammatory actions and an ability to act as a binding protein, are under investigation. Called also blastokinin.

Medical dictionary. 2011.

Look at other dictionaries:

  • uteroglobin — uteroglobin. См. бластокинин. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • Uteroglobin — Secretoglobin, family 1A, member 1 (uteroglobin) Identifiers Symbols SCGB1A1; CC10; CC16; CCPBP; CCSP; UGB; UP 1; UP1 External IDs …   Wikipedia

  • uteroglobin — Progesterone binding protein found in lagomorphs (rabbits, hares etc.), which is also a potent inhibitor of phospholipase A2. Forms an antiparallel dimer, linked by disulphide bonds at either end. A structurally related protein, CC10, is found in …   Dictionary of molecular biology

  • uteroglobin-adducin — An α/β heterodimeric protein found in renal tubule cells, thought to regulate ion transport through channels in the actin cytoskeleton. A mutant allele has been found in some patients with hypertension and it may be associated with the salt …   Medical dictionary

  • Secretoglobin, family 1A, member 1 (uteroglobin) — The founding member of the secretoglobin family of small, secreted, disulfide bridged dimeric proteins found only in mammals.cite journal | author = Laukaitis CM, Karn RC | title = Evolution of the secretoglobins: a genomic and proteomic view |… …   Wikipedia

  • бластокинин — uteroglobin, blastokinin утероглобин, бластокинин. Глобиновый белок, секретируемый клетками эндометрия в полость матки, известный у некоторых млекопитающих; предполагается наличие стимулирующего бластуляцию эффекта У. (отсюда его др. название… …   Молекулярная биология и генетика. Толковый словарь.

  • SCGB3A2 — Secretoglobin, family 3A, member 2, also known as SCGB3A2, is a human gene.cite web | title = Entrez Gene: SCGB3A2 secretoglobin, family 3A, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=117156|… …   Wikipedia

  • SCGB2A2 — protein Name=secretoglobin, family 2A, member 2 caption= width= HGNCid=70501 Symbol=TAS2R16 AltSymbols= EntrezGene=42502 OMIM=604867 RefSeq= UniProt=Q132963 PDB= ECnumber= Chromosome=11 Arm=q Band=12.3 LocusSupplementaryData= q13.1SCGB2A2 is a… …   Wikipedia

  • SCGB3A1 — Secretoglobin, family 3A, member 1, also known as SCGB3A1, is a human gene.cite web | title = Entrez Gene: SCGB3A1 secretoglobin, family 3A, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=92304|… …   Wikipedia

  • Mammaglobin-A — Secretoglobin, family 2A, member 2 Identifiers Symbols SCGB2A2; MGB1; MGC71974; UGB2 External IDs …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.