The annexins are a family of proteins first described in 1990. All of the annexin proteins share the property of binding calcium and phospholipids. The antiphospholipid antibody syndrome is due to a deficiency of annexin V. Annexin V normally forms a shield around certain phospholipid molecules that blocks their entry into coagulation (clotting) reactions. In the antiphospholipid antibody syndrome, the formation of this shield is disrupted by the abnormal antibodies. Without the shield, there is an increased quantity of phospholipid molecules on cell membranes, speeding up coagulation reactions and causing the abnormal blood clotting characteristic of the antiphospholipid antibody syndrome.
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A family of at least 13 Ca2+-dependent phospholipid-binding proteins that may act as mediators of intracellular calcium signals.

Medical dictionary. 2011.

Look at other dictionaries:

  • annexins — Group of calcium binding proteins that interact with acidic membrane phospholipids in membranes. They contain 4 or 8 repeats of a 61 amino acid domain that folds into 5 a helices. Also known by several other names (eg. lipocortins, endonexins),… …   Dictionary of molecular biology

  • calcimedins — Annexins …   Dictionary of molecular biology

  • calphobindins — Annexins V and VI (35 kD) found in placenta. Have substantial sequence homology with lipocortin and may function like calelectrin …   Dictionary of molecular biology

  • Annexin — Pfam box Symbol = Annexin Name = width = 220 caption = Structure of human annexin III. Pfam= PF00191 InterPro= IPR001464 SMART= PROSITE= PDOC00195 SCOP = 2ran TCDB = 1.A.31 OPM family= 43 OPM protein= 1w3w PDB=PDB3|1n00A:14 79 PDB3|1dk5B:15 80… …   Wikipedia

  • Annexin II — Structure cristallographique modélisée de l annexine II Annexine II (autres noms : Annexin II, Annexin A2, Annexin 2, Lipocortin II, Calpactin I heavy chain, Chromobindin 8, p. 36, Placental anticoagulant protein IV). UniProtKB/Swiss… …   Wikipédia en Français

  • ANXA4 — Annexin A4, also known as ANXA4, is a human gene.cite web | title = Entrez Gene: ANXA4 annexin A4| url = Cmd=ShowDetailView TermToSearch=307| accessdate = ] PBB Summary section title = summary text …   Wikipedia

  • ANXA11 — Annexin A11, also known as ANXA11, is a human gene.cite web | title = Entrez Gene: ANXA11 annexin A11| url = Cmd=ShowDetailView TermToSearch=311| accessdate = ] PBB Summary section title = summary… …   Wikipedia

  • ANXA9 — Annexin A9, also known as ANXA9, is a human gene.cite web | title = Entrez Gene: ANXA9 annexin A9| url = Cmd=ShowDetailView TermToSearch=8416| accessdate = ] PBB Summary section title = summary… …   Wikipedia

  • Vesicle (biology) — A vesicle is a small bubble of liquid within a cell. A more formal definition in cell biology, would be that a vesicle is a relatively small, intracellular, membrane enclosed sac that stores or transports substances. Vesicles form naturally… …   Wikipedia

  • ANXA6 — Annexin A6, also known as ANXA6, is a human gene. PBB Summary section title = summary text = Annexin VI belongs to a family of calcium dependent membrane and phospholipid binding proteins. Although their functions are still not clearly defined,… …   Wikipedia

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