trypsin

A proteolytic enzyme formed in the small intestine from trypsinogen by the action of enteropeptidase; a serine proteinase that hydrolyzes peptides, amides, esters, etc., at bonds of the carboxyl groups of l-arginyl or l-lysyl residues; it also produces the meromyosins.
- crystallized t. a purified preparation of the pancreatic enzyme; used as an adjunct to surgery for débridement of necrotic wounds and ulcers.

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tryp·sin 'trip-sən n
1) a crystallizable proteolytic enzyme that differs from pepsin in several ways (as in being most active in a slightly alkaline medium and in hydrolyzing esters as well as amides) and that is produced and secreted in the pancreatic juice in the form of inactive trypsinogen and activated in the intestine compare CHYMOTRYPSIN
2) a preparation from the pancreatic juice differing from pancreatin in containing principally proteolytic enzymes and used chiefly as a digestive and lytic agent

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n.
an enzyme that continues the digestion of proteins by breaking down peptones into smaller peptide chains (see peptidase). It is secreted by the pancreas in an inactive form, trypsinogen, which is converted in the duodenum to trypsin by the action of the enzyme enteropeptidase.

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tryp·sin (tripґsin) [EC 3.4.21.4] a serine endopeptidase that catalyzes cleavage of peptide bonds on the carboxyl side of either arginine or lysine. It is secreted by the pancreas as the proenzyme trypsinogen and converted to the active form in the small intestine by enteropeptidase; the active enzyme catalyzes the cleavage and activation of additional trypsinogen and other pancreatic proenzymes important to protein digestion.

Medical dictionary. 2011.

Look at other dictionaries:

  • Trypsin — 1 Vorhandene Strukturdaten …   Deutsch Wikipedia

  • Trypsin — Tryp sin, n. [Gr. ? a rubbing, fr. ? to rub, grind. So called because it causes protein to break up or to fall apart.] (physiol.) A proteolytic enzyme present in the pancreatic juice. Unlike the pepsin of the gastric juice, it acts in a neutral… …   The Collaborative International Dictionary of English

  • trypsin — trypsin. См. трипсин. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • Trypsīn — Trypsīn, das eiweißzerlegende Ferment des Bauchspeichels (s. d.) …   Meyers Großes Konversations-Lexikon

  • Trypsin — Trypsīn, s. Pankreatin …   Kleines Konversations-Lexikon

  • Trypsin — Trypsin, den Endopeptidasen zugehörendes, Proteine zu Oligopeptiden spaltendes Verdauungsenzym der Wirbeltiere und vieler Wirbelloser, das sein pH Optimum im alkalischen Bereich (pH 7–9) hat und ausschließlich Peptidbindungen abbaut, deren… …   Deutsch wörterbuch der biologie

  • trypsin — 1876, apparently from Gk. tripsis “rubbing” + chemical suffix IN (Cf. in) (2). Said to be so called because it first was obtained by rubbing the pancreas with glycerin …   Etymology dictionary

  • trypsin — [trip′sin] n. [Ger, prob. < Gr tryein, to wear away (see TRITE) + Ger (pe)psin: see PEPSIN] 1. a proteolytic enzyme in the pancreatic juice that hydrolyzes proteins to smaller polypeptides 2. any of several similar enzymes tryptic [trip′tik]… …   English World dictionary

  • Trypsin — protein Name=protease, serine, 1 (trypsin 1) caption=Crystal structure of Trypsin width= HGNCid=9475 Symbol=PRSS1 AltSymbols=TRY1 EntrezGene=5644 OMIM=276000 RefSeq=NM 002769 UniProt=P07477 PDB= ECnumber=3.4.21.4 Chromosome=7 Arm=q Band=32… …   Wikipedia

  • Trypsin 1 — Protease, serine, 1 (trypsin 1), also known as PRSS1, is a human gene. PBB Summary section title = summary text = This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the… …   Wikipedia

  • Trypsin — Tryp|sin 〈n. 11; unz.; Biochem.〉 eiweißspaltendes Enzym der Bauchspeicheldrüse [<grch. tryein „aufreiben“ + Pepsin] * * * Tryp|sin [vermutlich Kurzw. aus griech. trýein = aufreiben, erschöpfen, verzehren, pépsis = Verdauung u. ↑ in (3)], das;… …   Universal-Lexikon

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