trihexyphenidyl hydrochloride

A synthetic anticholinergic agent reputed to exert a higher degree of anticholinergic activity in the brain as compared with peripheral parasympathetic neuroeffector junctions. Widely used in the treatment of parkinsonism secondary to idiopathic or neuroleptic-induced parkinsonism.

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tri·hex·y·phen·i·dyl hy·dro·chlo·ride (tri-hek″sĭ-fenґĭ-dəl) [USP] an antidyskinetic with a direct antispasmodic effect on smooth muscle; believed to act by partially blocking central cholinergic receptors, so that cholinergic and dopaminergic activity in the basal ganglia is more balanced. It is used in the treatment of parkinsonism and for the control of drug-induced extrapyramidal reactions (except tardive dyskinesia), administered orally.

Medical dictionary. 2011.

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