topoisomerase

A type of enzyme converting (isomerizing) one topological version of DNA into another; acts by catalyzing the breakage and reformation of DNA phosphodiester linkages. [topo- + isomerase]

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topo·isom·er·ase .tō-pō-ī-'säm-ə-.rās, -.rāz n any of a class of enzymes that reduce supercoiling in DNA by breaking and rejoining one or both strands of the DNA molecule

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topo·isom·er·ase (to″po-i-somґə-rās) an enzyme that interconverts topoisomers of DNA by breaking and rejoining one or more phosphodiester bonds and altering the degree of supercoiling of the DNA.

Medical dictionary. 2011.

Look at other dictionaries:

  • Topoisomerase IV — is one of two type II topoisomerases in bacteria, the other being DNA gyrase. Like gyrase, topoisomerase IV is able to pass one double strand of DNA through another double strand of DNA, thereby changing the linking number of DNA by two in each… …   Wikipedia

  • topoisomerase II — topoisomerase II. = DNA gyrase (см.). (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • Topoisomerase — Topoisomerases (type I: EC 5.99.1.2, type II: EC 5.99.1.3) are enzymes that regulate the overwinding or underwinding of DNA. The winding problem of DNA arises due to the intertwined nature of its double helical structure. For example, during DNA… …   Wikipedia

  • Topoisomerase — Topoisomerasen Bezeichner Externe IDs CAS Nummer …   Deutsch Wikipedia

  • Topoisomerase I — Topoisomerasen Typ I Topoisomerase an DNA …   Deutsch Wikipedia

  • Topoisomerase II — ADN topoïsomérase Les ADN topoïsomérases (de type I : ADN topo isomérases et de type II : ADN gyrases) sont des enzymes qui contrôlent la structure topologique de l’ADN en générant des coupures transitoires dans celui ci et en… …   Wikipédia en Français

  • Topoisomérase — ADN topoïsomérase Les ADN topoïsomérases (de type I : ADN topo isomérases et de type II : ADN gyrases) sont des enzymes qui contrôlent la structure topologique de l’ADN en générant des coupures transitoires dans celui ci et en… …   Wikipédia en Français

  • Topoisomerase II — Topoisomerasen TypII Bezeichner Externe IDs CAS Num …   Deutsch Wikipedia

  • topoisomerase — topoizomerazė statusas T sritis chemija apibrėžtis Fermentas, katalizuojantis ciklinės DNR struktūrinius pokyčius. atitikmenys: angl. topoisomerase rus. топоизомераза …   Chemijos terminų aiškinamasis žodynas

  • topoisomerase — noun Etymology: top + isomerase Date: 1980 any of a class of enzymes that reduce supercoiling in DNA by breaking and rejoining one or both strands of the DNA molecule …   New Collegiate Dictionary

  • topoisomerase — noun Any of several enzymes that effect the topology of DNA, especially ones that relax supercoiling …   Wiktionary

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