A structural cytoplasmic protein, of a class known as intermediate filaments, bundles of which together form a tonofibril; a t. is made up of a variable number of related proteins, keratins, and is found in all epithelial cells, but is particularly well developed in the epidermis.

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tono·fil·a·ment -'fil-ə-mənt n a slender cytoplasmic organelle found esp. in some epithelial cells

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tono·fil·a·ment (ton″o-filґə-mənt) an intermediate filament composed of cytokeratin and occurring in epithelial cells, particularly those of the epidermis; tonofilaments participate in the formation of desmosomes and hemidesmosomes. The term is often used synonymously with keratin filament. See also tonofibril.

Medical dictionary. 2011.

Look at other dictionaries:

  • tonofilament — noun A structural filament of keratin present in the cytoplasm See Also: tonofibril …   Wiktionary

  • tonofibril — One of a system of fibers found in the cytoplasm of epithelial cells. See cytoskeleton, tonofilament. SYN: epitheliofibril, tenofibril. * * * tono·fi·bril fīb rəl, fib n a thin fibril made up of tonofilaments * * * n. a tiny fibre occurring in… …   Medical dictionary

  • Squamous-cell carcinoma — Squamous cell carcinoma, NOS Classification and external resources SCC of the skin tends to arise from pre malignant lesions, actinic keratoses; surface is usually scaly and often ulcerates (as shown here). ICD 10 …   Wikipedia

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