- conjunctivitis), lips and mucous membranes of the mouth, ulcerative gum disease (gingivitis), swollen glands in the neck (cervical lymphadenopathy) and a rash that is raised and bright red (maculoerythematous) in a glove-and-sock fashion over the skin of the hands and feet which becomes hard, swollen (edematous) and peels off. Also called the mucocutaneous lymph node syndrome. The name of mucocutaneous lymph node syndrome is quite descriptive because the disease is characterized by the typical changes in the mucus membranes that line the lips and mouth and by the enlarged and tender lymph glands. The syndrome was first described in the late 1960's in Japan by the pediatrician Tomisaku Kawasaki. Kawasaki disease affects the vascular system, and is now the main cause of acquired heart disease in children. It is most common in people of Asian descent, and is both more common and more deadly in males. The cause of the disease is a mystery. Current theories include viral causes or an environmental toxin. Treatment is usually with IVIG (intravenous immunoglobulin). To learn more, see Kawasaki Disease.
* * *Ka·wa·sa·ki disease .kä-wə-'sä-kē- also Ka·wa·sa·ki's disease -kēz- n an acute febrile disease of unknown cause affecting esp. infants and children that is characterized by a reddish macular rash esp. on the trunk, conjunctivitis, inflammation of mucous membranes (as of the tongue), erythema of the palms and soles followed by desquamation, edema of the hands and feet, and swollen lymph nodes in the neck called also mucocutaneous lymph node disease, mucocutaneous lymph node syndromeKa·wa·sa·ki kä-wä-sä-kē Tomisaku (fl 1961)Japanese pediatrician. Kawasaki first discovered mucocutaneous lymph node syndrome in Japanese children in 1961. In 1967 he published his findings based upon 50 case studies, all of which involved Japanese children five years old and younger. Since that original report, however, Kawasaki disease has been observed in other countries and in patients who are considerably older.
* * *a condition of unknown cause affecting young children, usually less than five years old, and characterized by fever, conjunctivitis, a sore throat, and a generalized rash and reddening of the palms and soles. This is followed by peeling of the fingers and toes. The fever usually persists for 1-2 weeks. In approximately one-fifth of children there is involvement of the coronary arteries and heart muscle (myocardium), resulting in myocarditis and aneurysm of the coronary arteries. About 2% of cases are fatal. The aneurysms will usually resolve spontaneously but slowly. Treatment involves aspirin therapy, and gammaglobulin has recently been shown to reduce the risk of coronary artery disease.T. Kawasaki (20th century), Japanese physician
* * *a syndrome of unknown etiology, usually affecting infants and young children, associated with vasculitis of the large coronary vessels and numerous other systemic signs, including fever, conjunctival injection, changes of the oropharyngeal mucosa, cervical lymphadenopathy, and maculoerythematous skin eruption that becomes confluent and bright red in a glove-and-sock distribution; the skin becomes indurated and edematous and often desquamates from the fingers and toes. Called also mucocutaneous lymph node syndrome.
Kawasaki disease. (A), Bilateral nonexudative scleral injection with perilimbic sparing; (B), diffuse palmar erythema.
Medical dictionary. 2011.
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Kawasaki disease — Classification and external resources A child showing characteristic strawberry tongue seen in Kawasaki disease ICD 10 M … Wikipedia
Kawasaki disease — noun a disease in young children with an unknown cause, giving rise to a rash, glandular swelling, and sometimes damage to the heart. Origin 1960s: named after the Japanese physician Tomisaku Kawasaki … English new terms dictionary
Kawasaki disease — mucocutaneous lymph node syndrome a condition of unknown cause affecting young children, usually less than five years old, and characterized by fever, conjunctivitis, a sore throat, and a generalized rash and reddening of the palms and soles.… … The new mediacal dictionary
Kawasaki disease — /kawəˈsaki dəziz/ (say kahwuh sahkee duhzeez) noun a rare but serious autoimmune disease of small children, causing blood vessel inflammation in many organs in the body. Also, Kawasaki syndrome, lymph node syndrome … Australian English dictionary
Kawasaki disease — noun Etymology: Tomisaku Kawasaki b1925 Japanese pediatrician Date: 1977 an acute illness of unknown cause that chiefly affects infants and children and is characterized especially by fever, rash, conjunctivitis, inflammation of lips and tongue,… … New Collegiate Dictionary
Kawasaki disease — noun an acute disease of young children characterized by a rash and swollen lymph nodes and fever; of unknown cause • Syn: ↑mucocutaneous lymph node syndrome • Hypernyms: ↑disease … Useful english dictionary
Kawasaki disease — Pathol. an acute illness of unknown cause, occurring primarily in children, characterized by high fever, swollen lymph glands, rash, redness in mouth and throat, and joint pain. [1980 85; after Japanese pediatrician Tomisaku Kawasaki, who first… … Universalium
Kawasaki disease — n. acute vasculitis that occurs mainly in children under 5 years of age that was first described in the late 1960 s by a Japanese pediatrician named Tomisaku Kawasaki that can cause coronary artery aneurysms or heart attacks and sudden death in… … English contemporary dictionary
Kawasaki disease — Acute inflammatory disease with systemic angiitis, most commonly occurring in infants and young children. Cause uncertain … Dictionary of molecular biology
Kawasaki disease — noun an illness of childhood that causes fever, lymphadenopathy, elevated platelet count, and a variety of other symptoms. Syn: Kawaski syndrome, lymph node syndrome, mucocutaneous lymph node syndrome … Wiktionary