A diuretic agent that blocks the renal tubular actions of aldosterone. It increases the urinary excretion of sodium and chloride, decreases the excretion of potassium and ammonium, and reduces the titratable acidity of the urine; most effectively used to potentiate the natriuretic action and reduce the potassium excretion produced by other diuretics.

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spi·ro·no·lac·tone .spī-rə-nō-'lak-.tōn, spi-.rō-nə- n an aldosterone antagonist C24H32O4S that promotes diuresis and sodium excretion and is used to treat essential hypertension, edema with congestive heart failure, hepatic cirrhosis with ascites, nephrotic syndrome, and idiopathic edema

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a synthetic corticosteroid that inhibits the activity of the hormone aldosterone and is used as a potassium-sparing diuretic to treat heart failure, high blood pressure, and fluid retention (oedema). It is administered by mouth; side-effects may include headache, stomach upsets, breast enlargement and impotence (in men), and menstrual disturbances (in women). Trade name: Aldactone.

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spir·o·no·lac·tone (spi″rə-no-lakґtōn) [USP] a synthetic 17-spirolactone steroid and aldosterone antagonist that is a potassium-sparing diuretic; it blocks the aldosterone-dependent exchange of sodium and potassium in the distal renal tubule, which increases excretion of sodium and water and decreases excretion of potassium. Used in the treatment of edema, hypokalemia, primary aldosteronism, and, usually in combination with other drugs, hypertension.

Medical dictionary. 2011.

Look at other dictionaries:

  • Spironolactone — Systematic (IUPAC) name 7α Acetylthio 3 oxo 17α pregn 4 ene 21,17 carbolactone OR (1 S,2R,2 R,9 R,10 R,11 S,15 S) 9 (acetylsulfanyl) 2 ,15 dimethylspiro[oxolane 2,14 tetracyclo[ …   Wikipedia

  • Spironolactone — Formule chimique de la spironolactone Général No CAS …   Wikipédia en Français

  • spironolactone — ● spironolactone nom féminin Médicament chimique de structure analogue à celle de l aldostérone et aux effets antagonistes de ceux de cette hormone. (La spironolactone est employée dans le traitement de différents œdèmes.) …   Encyclopédie Universelle

  • spironolactone — n. a synthetic corticosteroid that inhibits the activity of the hormone aldosterone and is used as a potassium sparing diuretic to treat fluid retention (oedema) in cirrhosis, ascites, and severe heart failure. It is also used in treating… …   The new mediacal dictionary

  • spironolactone — Aldosterone antagonist: diuretic; used to treat low renin hypertension, and Conn s syndrome (in which there is overproduction of aldesterone) …   Dictionary of molecular biology

  • spironolactone — /spuy reuh noh lak tohn, spuy roh , ron euh /, n. Pharm. a steroid, C24H32O4S, used in combination with other drugs as a diuretic and antihypertensive. [1955 60; alter. of spirolactone; see SPIRO 2, LACTONE] * * * …   Universalium

  • spironolactone — noun A particular diuretic and antiandrogen …   Wiktionary

  • spironolactone — [ˌspʌɪrənə(ʊ) laktəʊn] noun Medicine a steroid drug used in the treatment of certain types of oedema and hypertension. Origin 1960s: from spiro 1 (in sense 2) + lactone, with the insertion of one …   English new terms dictionary

  • spironolactone — spi·ro·no·lactone …   English syllables

  • spironolactone — noun a synthetic corticosteroid (trade name Aldactone) used to treat hypertension • Syn: ↑Aldactone • Usage Domain: ↑trade name (for: ↑Aldactone) • Hypernyms: ↑corticosteroid, ↑ …   Useful english dictionary

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