A potent HMG-CoA reductase (the rate-limiting enzyme for cholesterol biosynthesis) inhibitor. Used for the treatment of hyperlipidemia; similar to lovastatin.

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sim·va·stat·in 'sim-və-.stat-ən, .sim-və-'stat- n a semisynthetic lipid-lowering drug C25H38O5 derived from a compound produced by a mold of the genus Aspergillus (A. terreus) and administered orally to lower a high cholesterol level in the blood by inhibiting the action of an enzyme catalyzing the synthesis of cholesterol see vytorin, ZOCOR

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a drug used to reduce abnormally high levels of cholesterol in the blood (see statin). Its actions and side-effects are similar to those of atorvastatin. Trade name: Zocor.

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sim·va·stat·in (simґvə-stat″in) [USP] an antihyperlipidemic agent that is an HMG-CoA reductase inhibitor, used to lower blood lipid levels in the treatment of hypercholesterolemia and other forms of dyslipidemia and to reduce the risk of morbidity and mortality associated with atherosclerosis and coronary heart disease; administered orally.

Medical dictionary. 2011.

Look at other dictionaries:

  • Simvastatin — Systematic (IUPAC) name …   Wikipedia

  • simvastatin — sim va*stat in, n. a chemical substance ({C25H38O5}) having inhibitory activity on the enzyme HMG CoA reductase, and used in medicine to reduce cholesterol levels in blood. Syn: synvinolin; MK 733; Zocor. [PJC] …   The Collaborative International Dictionary of English

  • Simvastatin — Strukturformel Allgemeines Freiname Simvastatin …   Deutsch Wikipedia

  • simvastatin — noun an oral lipid lowering medicine (trade name Zocor) administered to reduce blood cholesterol levels; recommended after heart attacks • Syn: ↑Zocor • Usage Domain: ↑trade name (for: ↑Zocor) • Hypernyms: ↑ …   Useful english dictionary

  • simvastatin — noun Etymology: sim (probably alteration of synthetic) + lovastatin Date: 1987 a semisynthetic drug C25H38O5 that decreases the level of cholesterol in the bloodstream and is derived from a compound produced by a mold (Aspergillus terreus) …   New Collegiate Dictionary

  • simvastatin — sim·va·stat·in (sĭm və stătʹn) n. A statin, C25H38O5, that blocks the body s synthesis of cholesterol and is administered especially to individuals at risk for heart disease.   [sim (perhaps alteration of syn , pref. indicating attachment on the… …   Universalium

  • simvastatin — noun A hypolipidemic drug used to control hypercholesterolemia and to prevent cardiovascular disease …   Wiktionary

  • simvastatin — n. a drug used to reduce abnormally high levels of cholesterol in the blood (see statin). Its actions and side effects are similar to those of atorvastatin. Trade names: Zocor …   The new mediacal dictionary

  • Ezetimibe/simvastatin — Drugbox type = combo width = 220px width2 = 171px component1 = Ezetimibe class1 = via Niemann Pick C1 Like 1 protein component2 = Simvastatin class2 = Statin HMG CoA reductase inhibitor CAS number = ATC prefix = C10 ATC suffix = BA02 PubChem =… …   Wikipedia

  • Scandinavian Simvastatin Survival Study — The Scandinavian Simvastatin Survival Study (also known under the abbreviation 4S) is a multicenter clinical trial that was performed in 1990s in Scandinavia.The objective of the study was to assess effect of a cholesterol lowering drug called… …   Wikipedia

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