renin

A term originally used for a pressor substance obtained from rabbits' kidneys, now an enzyme that converts angiotensinogen to angiotensin I. SYN: angiotensinogenase.

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re·nin 'rē-nənalso 'ren-ən n a proteolytic enzyme of the blood that is produced and secreted by the juxtaglomerular cells of the kidney and hydrolyzes angiotensinogen to angiotensin I

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n.
an enzyme released into the blood by the kidney in response to stress. It reacts with a substrate from the liver to produce angiotensin, which causes constriction of blood vessels and thus an increase in blood pressure. Excessive production of renin results in the syndrome of renal hypertension.

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re·nin (reґnin) [EC 3.4.23.15] an enzyme of the hydrolase class that catalyzes cleavage of the leucine-leucine bond in angiotensinogen to generate angiotensin I. The enzyme is synthesized as inactive prorenin in the kidney and released into the blood in the active form in response to various metabolic stimuli. See also renin-angiotensin-aldosterone system, under system. Not to be confused with rennin (chymosin).

Medical dictionary. 2011.

Look at other dictionaries:

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  • renin — 1894, from L. renes “kidneys” + in …   Etymology dictionary

  • renin — [rē′nin] n. [< L renes, kidneys + IN1] a proteolytic enzyme, formed in the kidneys, that helps produce angiotensin, which is a powerful pressor responsible for hypertension …   English World dictionary

  • Renin — Protbox Name=Renin Photo=Renin.png Caption=Molecular structure of renin HGNCid = 9958 Symbol = REN AltSymbols = Names=Angiotensinogenase Chromosome = 1 Arm = q Band = 32 LocusSupplementaryData = Gene= Gene type= Protein length=406 Molecular… …   Wikipedia

  • Renin — Re|nin [lat. ren = Niere; ↑ in (3)], das; s, e; Syn.: Angiotensinogenase: in der Niere gebildete Aspartat Proteinase vom MG 43 000, die Angiotensinogen zu ↑ Angiotensin I spaltet. Aus diesem setzt ↑ ACE Angiotensin II frei, das seinerseits u. a.… …   Universal-Lexikon

  • renin — /ree nin/, n. Biochem. a proteolytic enzyme secreted by the kidneys that is involved in the release of angiotensin. [1890 95; REN(I) + IN2] * * * ▪ enzyme       enzyme secreted by the kidney (and also, possibly, by the placenta) that breaks down… …   Universalium

  • renin — noun ˈriːnɨn An circulating enzyme released by mammalian kidneys that converts angiotensinogen to angiotensin I. Because its activity ultimately leads to formation of angiotensin II and aldosterone, this hormone plays a role in maintaining blood… …   Wiktionary

  • renin — n. an enzyme released into the blood by the kidney in response to stress. It reacts with a substrate from the liver to produce angiotensin, which causes constriction of blood vessels and thus an increase in blood pressure. Excessive production of …   The new mediacal dictionary

  • renin — reninas statusas T sritis chemija apibrėžtis Endopeptidazė. atitikmenys: angl. renin rus. ренин …   Chemijos terminų aiškinamasis žodynas

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