- One of a group of enzymes (EC 2.4.2.x, pentosyltransferases) that transfers d-ribose 5-phosphate from 5-phospho-α-d-ribosyl pyrophosphate to a purine, pyrimidine, or pyridine acceptor, forming a 5′-nucleotide and pyrophosphate, or d-ribose from d-ribosyl phosphate to a base, forming a nucleoside, or similar pentose transfers; important in nucleotide biosynthesis. Specific phosphoribosyltransferases are preceded by the name of the acceptor base, e.g., uracil p. ( i.e., uracil + PRPP ⇋ UMP + pyrophosphate).
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* * *phos·pho·ri·bo·syl·trans·fer·ase (fos″fo-ri″bo-səl-transґfər-ās) a term used in the recommended and trivial names of some pentosyltransferases [EC 2.4.2] to denote those that catalyze the transfer of ribose 5-phosphate, usually from phosphoribosylpyrophosphate, to a purine or pyrimidine to form a 5′ nucleotide and inorganic pyrophosphate. These enzymes are important in the biosynthesis of nucleotides.
Medical dictionary. 2011.
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