phosphatase

Any of a group of enzymes (EC 3.1.3.x) that liberate orthophosphate from phosphoric esters. SEE ALSO: phosphohydrolases.
- acid p. a p. with an optimum pH of less than 7.0 (for several isozymes, it is 5.4), notably present in the prostate gland; demonstrable in lysosomes with Gomori nonspecific acid p. stain; it hydrolyzes many orthophosphoric monoesters.
- alkaline p. a p. with an optimum pH of above 7.0 ( e.g., 8.6), present ubiquitously; localized cytochemically in membranes by modifications of Gomori nonspecific alkaline p. stain; it hydrolyzes many orthophosphoric monoesters; low levels of this enzyme are seen in cases of hypophosphatasia.

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phos·pha·tase 'fäs-fə-.tās, -.tāz n an enzyme that accelerates the hydrolysis and synthesis of organic esters of phosphoric acid and the transfer of phosphate groups to other compounds:
a) ALKALINE PHOSPHATASE
b) ACID PHOSPHATASE

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n.
one of a group of enzymes capable of catalysing the hydrolysis of phosphoric acid esters. An example is glucose-6-phosphatase, which catalyses the hydrolysis of glucose-6-phosphate to glucose and phosphate. Phosphatases are important in the absorption and metabolism of carbohydrates, nucleotides, and phospholipids and are essential in the calcification of bone. Acid phosphatase is present in kidney, semen, serum, and the prostate gland. Alkaline phosphatase occurs in teeth, developing bone, plasma, kidney, and intestine.

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phos·pha·tase (fosґfə-tās) a term used in the recommended names of some enzymes of the hydrolase class that are phosphoric monoester hydrolases [EC 3.1.3], catalyzing the release of inorganic phosphate from phosphoric esters. See also acid phosphatase and alkaline phosphatase.

Medical dictionary. 2011.

Look at other dictionaries:

  • phosphatase — [ fɔsfataz ] n. f. • av. 1949; de phosphate et ase ♦ Biochim. Enzyme qui catalyse la libération d acide phosphorique à partir de ses esters organiques. ● phosphatase nom féminin Enzyme libérant de l acide phosphorique, présente dans de nombreux… …   Encyclopédie Universelle

  • phosphatase — [fäs′fə tās΄] n. [< PHOSPHATE + ASE] any of various enzymes, found in body tissues and fluids, that hydrolyze phosphoric acid esters of organic compounds, liberating phosphate ions …   English World dictionary

  • Phosphatase — A phosphatase is an enzyme that removes a phosphate group from its substrate by hydrolysing phosphoric acid monoesters into a phosphate ion and a molecule with a free hydroxyl group (see dephosphorylation). This action is directly opposite to… …   Wikipedia

  • Phosphatase — Une phosphatase est une enzyme dont la fonction est d enlever un groupe phosphate d une molécule simple ou d une macromolécule biologique, par hydrolyse. En biotechnologie, elle peut agir sur l ADN et sur l ARN afin d empêcher leur… …   Wikipédia en Français

  • Phosphatase — Phosphatasen Enzymklassifikationen EC, Kategorie …   Deutsch Wikipedia

  • phosphatase — n. one of a group of enzymes capable of catalysing the hydrolysis of phosphoric acid esters. An example is glucose 6 phosphatase, which catalyses the hydrolysis of glucose 6 phosphate to glucose and phosphate. Phosphatases are important in the… …   The new mediacal dictionary

  • phosphatase — noun Date: 1912 an enzyme that accelerates the hydrolysis and synthesis of organic esters of phosphoric acid and the transfer of phosphate groups to other compounds: a. alkaline phosphatase b. acid phosphatase …   New Collegiate Dictionary

  • phosphatase — fosfatazė statusas T sritis chemija apibrėžtis Fermentas, katalizuojantis fosfatų atskėlimą. atitikmenys: angl. phosphatase rus. фосфатаза …   Chemijos terminų aiškinamasis žodynas

  • phosphatase — (fos fah teīs ) An enzyme that catalyzes the hydrolytic removal of phosphate from molecules …   Dictionary of microbiology

  • phosphatase — /fos feuh tays , tayz /, n. Biochem. any of several classes of esterases of varying specificity that catalyze the hydrolysis of phosphoric esters. [1910 15; PHOSPHATE + ASE] * * * …   Universalium

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