A keto derivative of proline that is formed nonenzymatically from glutamate, glutamine, and γ-glutamylated peptides; it is also produced by the action of γ-glutamylcyclotransferase; elevated levels of o. are often associated with problems of glutamine or glutathione metabolism. SYN: 5-pyrrolidone-2-carboxylic acid, pyroglutamic acid, pyrrolidone-5-carboxylate.

* * *

5-oxo·pro·line (ok″so-proґlēn) a ninhydrin-negative, acidic lactam of glutamic acid occurring at the N-terminus of several peptides and proteins. Called also pyroglutamic acid or pyroglutamate.

Medical dictionary. 2011.

Look at other dictionaries:

  • 4-oxoproline reductase — In enzymology, a 4 oxoproline reductase (EC number| is an enzyme that catalyzes the chemical reaction:4 hydroxy L proline + NAD+ ightleftharpoons 4 oxoproline + NADH + H+Thus, the two substrates of this enzyme are 4 hydroxy L proline… …   Wikipedia

  • 4-oxoproline reductase — SYN: 4 hydroxyproline oxidase …   Medical dictionary

  • Gamma-glutamylcyclotransferase — In enzymology, a gamma glutamylcyclotransferase (EC number| is an enzyme that catalyzes the chemical reaction:(5 L glutamyl) L amino acid ightleftharpoons 5 oxoproline + L amino acidHence, this enzyme has one substrate, (5 L glutamyl) L… …   Wikipedia

  • 4-hydroxyproline — 4 Hydroxy 2 pyrrolidinecarboxylic acid; the trans l isomer is a pyrrolidine found among the hydrolysis products of collagen; not found in proteins other than those of connective tissue. A vitamin C deficiency will result in impaired formation of… …   Medical dictionary

  • 5-oxoprolinase — An enzyme that catalyzes the ATP dependent hydrolysis of l 5 oxoproline (ATP + l 5 oxoproline → ADP + orthophosphate + l glutamate); a deficiency of this enzyme will result in 5 oxoprolinuria …   Medical dictionary

  • 5-oxoprolinuria — Elevated levels of 5 oxoproline in the urine. * * * 5 oxo·pro·lin·u·ria (ok″so pro″lin uґre ə) 1. excess of 5 oxoproline in the urine. 2. generalized deficiency of glutathione synthetase; see glutathione synthetase deficiency …   Medical dictionary

  • pyroglutamic acid — SYN: 5 oxoproline. * * * py·ro·glu·tam·ic ac·id (pi″ro gloo tamґik) 5 oxoproline …   Medical dictionary

  • glutathione synthetase deficiency — glu·ta·thi·one syn·the·tase de·fi·cien·cy (gloo″tə thiґōn sinґthə tās) an autosomal recessive aminoacidopathy due to mutation in the GSS gene (locus: 20q11.2), which encodes glutathione synthetase, resulting in decreased …   Medical dictionary

  • Pyroglutamic acid — Chembox new Reference= [ Merck Index , 11th Edition, 8012.] ImageFile=Pyroglutamic acid.svg ImageSize=180px IUPACName=5 oxopyrrolidine 2 carboxylic acid OtherNames=Pyrrolidonecarboxylic Acid, Pidolic acid, Pyroglutamate, 5 oxoproline Section1=… …   Wikipedia

  • List of EC numbers (EC 1) — This list contains a list of EC numbers for the first group, EC 1, oxidoreducatases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 1.1 Acting on the CH OH …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.