- UDP-glucuronosyltransferase) results in a condition called Gilbert's disease in which there are mild elevations of bilirubin pigment in the blood. The elevated bilirubin pigment can sometimes cause mild yellowing (jaundice) of the eyes. People with Gilbert's disease are otherwise entirely normal with no other signs or symptoms and their liver enzymes in blood serum are also entirely normal. There is no need for treatment, and the prognosis (outlook) is excellent. The gene for UDP-glucuronosyltransferase has been mapped a non-sex chromosome (chromosome 2). A single dose of the Gilbert version of the gene is enough to produce Gilbert's disease. (The condition is said therefore to be an autosomal dominant trait). If someone has Gilbert's disease, the chance of their transmitting the Gilbert gene to each of their children is one-half (50%) and each child who gets the gene gets Gilbert's disease. Gilbert's disease is a frequent finding in people in the U.S. and Europe. The condition is usually detected serendipitously (purely by accident) in the course of routine blood screening. Gilbert's disease is thus an accidentally-encountered enzyme abnormality of no health consequence.
Medical dictionary. 2011.
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UDP-Glucuronosyltransferase — UDP GT1 A1 Masse/Länge Primärstruktur 508 Aminosäuren … Deutsch Wikipedia
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Glucuronosyltransferase — Protein Name=PAGENAME caption= Symbol=UGT1A1 AltSymbols= HGNCid=12530 Chromosome=2 Arm=q Band=37 LocusSupplementaryData= ECnumber=18.104.22.168 OMIM=191740 EntrezGene=54658 RefSeq=NM 000463 UniProt=P22309 PDB=Uridine 5 diphospho… … Wikipedia
UDP-glucuronosyltransferase — UDP glucuronosyltransferase. См. УДФ глюкуронозилтрансфераза. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) … Молекулярная биология и генетика. Толковый словарь.
UDP-glucuronosyltransferase — A liver enzyme essential to the disposal of bilirubin (the chemical that results from the normal breakdown of hemoglobin from red blood cells). An abnormality of this enzyme (UDP glucuronosyltransferase) results in a condition called Gilbert s… … Medical dictionary
glucuronosyltransferase — Any of a family of enzymes that transfer d glucuronate to the acceptor named, forming glucuronosides; e.g., UDPglucuronate bilirubin g.. * * * glu·cu·ron·o·syl·trans·fer·ase (gloo″ku ron″o səl transґfər ās) [EC… … Medical dictionary
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