lipoprotein lipase

An enzyme that hydrolyzes one fatty acid from a triacylglycerol; its activity is enhanced by heparin and inactivated by heparinase. It is activated by apolipoprotein C-II; a deficiency of l. is associated with familial hyperlipoproteinemia type I. SEE ALSO: familial l. inhibitor, clearing factors, under factor. SYN: diacylglycerol lipase, diglyceride lipase.

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lipo·pro·tein li·pase (lip″o-proґtēn liґpās) [EC 3.1.1.34] an enzyme of the hydrolase class that catalyzes the hydrolytic cleavage of fatty acyl groups from triglycerides (or di- or monoglycerides) in chylomicrons, very-low-density lipoproteins, and low-density lipoproteins. It occurs on capillary endothelial surfaces, especially in mammary, muscle, and adipose tissue, and requires apolipoprotein C-II as a cofactor.

Medical dictionary. 2011.

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  • lipase — 1. In general, any fat splitting or lipolytic enzyme; a carboxylesterase; e.g., triacylglycerol l., phospholipase A2, lipoprotein l.. 2. SYN: triacylglycerol l.. * * * li·pase lip .ās, līp , .āz n any enzyme (as one secreted by the pancreas) that …   Medical dictionary

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