ligand

1. Any individual atom, group, or molecule attached to a central metal ion by multiple coordinate bonds; e.g., the porphyrin portion of heme, the corrin nucleus of the B12 vitamins. 2. An organic molecule attached to a tracer element, e.g., a radioisotope. 3. A molecule that binds to a macromolecule, e.g., a l. binding to a receptor. 4. The analyte in competitive binding assays, such as radioimmunoassay. 5. An atom or group covalently attached to a specified carbon atom in an organic molecule. [L. ligo, to bind]
- addressin ligands ligands on cells for specific homing receptors on lymphocytes.
- Fas l. a molecule on the surface of cytotoxic T cells that binds to its receptor, Fas, on the surface of other cells, initiating apoptosis in the target cell.

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li·gand 'lig-ənd, 'līg- n a group, ion, or molecule coordinated to a central atom or molecule in a complex
li·gand·ed -əd adj

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n.
a molecule that binds to another molecule, as in antigen-antibody and hormone-receptor bondings.

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li·gand (liґgand) (ligґənd) [L. ligare to tie or bind] 1. a molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. 2. a molecule that donates or accepts a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex.

Medical dictionary. 2011.

Look at other dictionaries:

  • ligand — [ ligɑ̃ ] n. m. • 1959; mot angl., du lat. ligandum, gérond. de ligare « lier » ♦ Chim. Molécule, ion uni à l atome central d un complexe par une liaison de coordinence. ♢ Biochim. Petite molécule se fixant à une protéine par des liaisons… …   Encyclopédie Universelle

  • ligand — ligand. См. лиганд. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • ligand — (n.) 1952, from L. ligandus, gerundive of ligare to bind (see LIGAMENT (Cf. ligament)) …   Etymology dictionary

  • ligand —  Ligand  Лиганд   Атом, ион или молекула, непосредственно связанный(ая) с одним или несколькими центральными (комплексообразующими) атомами металла в комплексном соединении. Чаще всего такое связывание происходит с образованием так называемой… …   Толковый англо-русский словарь по нанотехнологии. - М.

  • ligand — [lig′ənd, lī′gənd] n. [< L ligandum, ger. of ligare, to bind: see LIGATURE] an atom, group, ion, radical, or molecule which forms a coordination complex with a central atom or ion …   English World dictionary

  • Ligand — This article is about ligands in inorganic chemistry. For ligands in biochemistry, see Ligand (biochemistry). For other uses, see Ligand (disambiguation). Cobalt complex [HCo(CO)4] with five ligands In coordination chemistry, a ligand is an ion… …   Wikipedia

  • Ligand — Die Bezeichnung Ligand (lat. ligare = binden) stammt aus der Komplexchemie (Organometallchemie, Metallorganik und Bioanorganik) und bezeichnet ein Atom oder Molekül, welches über eine dative Bindung (koordinative Bindung) an ein zentrales Metall… …   Deutsch Wikipedia

  • ligand — /luy geuhnd, lig euhnd/, n. 1. Biochem. a molecule, as an antibody, hormone, or drug, that binds to a receptor. 2. Chem. a molecule, ion, or atom that is bonded to the central metal atom of a coordination compound. Cf. complexing agent. [1945 50; …   Universalium

  • Ligand — Cette page d’homonymie répertorie les différents sujets et articles partageant un même nom. Ligand est un terme scientifique utilisé pour caractériser certains types d interactions. En chimie : Ligand (chimie) En biologie : Ligand… …   Wikipédia en Français

  • ligand — Any molecule that binds to another; in normal usage a soluble molecule such as a hormone or neurotransmitter, that binds to a receptor. The decision as to which is the ligand and which the receptor is often a little arbitrary when the broader… …   Dictionary of molecular biology

  • ligand — ligandas statusas Aprobuotas sritis augalininkystė apibrėžtis Molekulė ar jonas, kompleksiniame junginyje susijungęs koordinaciniu ryšiu su centriniu atomu (kompleksodariu). atitikmenys: angl. ligand vok. Ligande, f rus. лиганд pranc. ligand, m… …   Lithuanian dictionary (lietuvių žodynas)

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