lecithin-cholesterol acyltransferase

An enzyme that reversibly transfers an acyl residue from a lecithin to cholesterol, forming a 1-acylglycerophosphocholine (a lysolecithin) and a cholesteryl ester; a deficiency of this enzyme leads to an accumulation of unesterified cholesterol in plasma resulting in anemia, proteinuria, renal failure, and corneal opacities; LCAT is also low in individuals with fish eye disease. SYN: lecithin acyltransferase.

Medical dictionary. 2011.

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  • Lecithin-cholesterol acyltransferase — (LCAT, also called phosphatidylcholine sterol O acyltransferase) is an enzyme which converts free cholesterol into cholesteryl ester (a more hydrophobic form of cholesterol) which is then sequestered into the core of a lipoprotein particle… …   Wikipedia

  • Lecithin cholesterol acyltransferase deficiency — Classification and external resources ICD 10 E78.6 ICD 9 272.5 …   Wikipedia

  • Lecithin-Cholesterin-Acyltransferase — Masse/Länge Primärstruktur 416 Aminosäuren …   Deutsch Wikipedia

  • Acyltransferase — Acyl Acyltransferase is a type of transferase enzyme that acts upon acyl groups. Examples include: Glyceronephosphate O acyltransferase Lecithin cholesterol acyltransferase See also Acetyltransferase …   Wikipedia

  • lecithin — Traditional term for 1,2 diacyl sn glycero 3 phosphocholines or 3 sn phosphatidylcholines, phospholipids that on hydrolysis yield two fatty acid molecules and a molecule each of glycerophosphoric acid and choline. In some varieties of l., both… …   Medical dictionary

  • Phosphatidylcholine-sterol O-acyltransferase — In enzymology, a phosphatidylcholine sterol O acyltransferase (EC number|2.3.1.43) is an enzyme that catalyzes the chemical reaction:phosphatidylcholine + a sterol ightleftharpoons 1 acylglycerophosphocholine + a sterol esterThus, the two… …   Wikipedia

  • LCAT — • lecithin cholesterol acyltransferase …   Dictionary of medical acronyms & abbreviations

  • LCAT — Abbreviation for lecithin cholesterol acyltransferase. * * * lecithin cholesterol acyltransferase * * * lecithin cholesterol acyltransferase; see phosphatidylcholine–sterol O acyltransferase …   Medical dictionary

  • Choline acetyltransferase — Identifiers EC number 2.3.1.6 CAS number 9012 78 6 …   Wikipedia

  • lipid — /lip id, luy pid/, n. Biochem. any of a group of organic compounds that are greasy to the touch, insoluble in water, and soluble in alcohol and ether: lipids comprise the fats and other esters with analogous properties and constitute, with… …   Universalium

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