- Aldose reductase inhibitor
- A class of drugs used to prevent eye and nerve damage in diabetes. Aldose reductase is an enzyme that is normally present in the eye and in many other parts of the body. It helps change glucose into a sugar alcohol called sorbitol. Too much sorbitol trapped in eye and nerve cells can damage these cells, leading to retinopathy (retinal disease) and neuropathy (nerve disease). Drugs that prevent or slow the action of aldose reductase may represent a means to prevent or delay these complications of diabetes.
Medical dictionary. 2011.
Look at other dictionaries:
Aldose reductase inhibitor — Aldose reductase inhibitors are a class of drugs being studied as a way to prevent eye and nerve damage in people with diabetes. MechanismTheir target, aldose reductase, is an enzyme that is normally present in many other parts of the body, and… … Wikipedia
aldose reductase inhibitor — (Pharmacology) class of drugs which inhibit activity of the aldose reductase enzyme (currently being studied as a possible treatment for eye and nerve damage in diabetics) … English contemporary dictionary
Aldose reductase — (or aldehyde reductase) is an enzyme in carbohydrate metabolism that converts an aldose to a sugar alcohol, using NADPH as the reducing agent.The enzyme can be inhibited by aldose reductase inhibitors.ReactionsSpecific reactions catalyzed by this … Wikipedia
Dihydrofolate reductase inhibitor — A dihydrofolate reductase inhibitor is a molecule that inhibits the function of dihydrofolate reductase, and is a type of antifolate. Since folate is needed by rapidly dividing cells to make thymine, this effect may be used to therapeutic… … Wikipedia
Monoamine oxidase inhibitor — MAOI redirects here. For the Easter Island statues, see Moai. Monoamine oxidase Monoamine oxidase inhibitors (MAOIs) are a class of antidepressant drugs prescribed for the treatment of depression. They are particularly effective in treating… … Wikipedia
Phosphodiesterase inhibitor — A phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), therefore preventing the inactivation of the intracellular second messengers cyclic adenosine monophosphate (cAMP) and… … Wikipedia
COX-2 inhibitor — COX 2 selective inhibitor is a form of non steroidal anti inflammatory drug (NSAID) that directly targets COX 2, an enzyme responsible for inflammation and pain. Targeting selectivity for COX 2 reduces the risk of peptic ulceration, and is the… … Wikipedia
Acetylcholinesterase inhibitor — Acetylcholine … Wikipedia
Dihydropteroate synthase inhibitor — A dihydropteroate synthetase inhibitor is a drug that inhibits the action of dihydropteroate synthetase. Most are sulfonamides. Tetrahydrofolate synthesis pathway In bacteria, antibacterial sulfonamides act as competitive inhibitors of the enzyme … Wikipedia
Reverse-transcriptase inhibitor — Reverse transcriptase inhibitors (RTIs) are a class of antiretroviral drug used to treat HIV infection, tumors, and cancer. RTIs inhibit activity of reverse transcriptase, a viral DNA polymerase enzyme that retroviruses need to reproduce.… … Wikipedia