hydroxyurea

An oral antineoplastic agent that inhibits DNA synthesis; used in the treatment of a variety of malignancies including melanoma, chronic myelocytic leukemia, and carcinoma of the ovary. SYN: hydroxycarbamide.

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hy·droxy·urea -yu̇-'rē-ə n an antineoplastic drug CH4N2O2 used esp. to treat melanoma, chronic myelogenous leukemia, and malignant tumors (as of the ovary or neck)

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n.

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hy·droxy·urea (hi-drok″se-u-reґə) [USP] an inhibitor of the enzyme ribonucleoside diphosphate reductase, which catalyzes the conversion of ribonucleotides to deoxyribonucleotides, an essential step in DNA synthesis. It is used as an antineoplastic agent primarily for treatment of busulfan-resistant chronic granulocytic leukemia, and also for the treatment of carcinoma of the head and neck, ovary, and cervix, malignant melanoma, and polycythemia vera; administered orally. It is also used orally in sickle cell disease to reduce the frequency of painful crises and to reduce the need for blood transfusions.

Medical dictionary. 2011.

Look at other dictionaries:

  • Hydroxyurea — or hydroxycarbamide (the latter being the recommended International Nonproprietary Name) is an antineoplastic drug used in hematological malignancies, specifically polycythemia vera and essential thrombocytosis. It is also used to reduce the rate …   Wikipedia

  • Hydroxyurea — Strukturformel Allgemeines Freiname Hydroxycarbamid Andere Namen …   Deutsch Wikipedia

  • hydroxyurea — noun Date: 1949 a drug CH4N2O2 used to treat some forms of leukemia, melanoma, and malignant tumors …   New Collegiate Dictionary

  • hydroxyurea — Inhibitor of DNA synthesis (but not repair) …   Dictionary of molecular biology

  • hydroxyurea — /huy drok see yoo ree euh, yoor ee euh/, n. Pharm. a synthetic compound, CH4N2O2, used in cancer therapy. [1945 50; HYDROXY + UREA] * * * …   Universalium

  • hydroxyurea — noun The hydroxylated derivative of urea, NHCO NHOH, used as an antineoplastic drug; any N or O derivative of this compound …   Wiktionary

  • hydroxyurea — hy·droxy·urea …   English syllables

  • hydroxyurea — n.; see hydroxycarbamide …   The new mediacal dictionary

  • hydroxyurea — An anticancer drug that belongs to the family of drugs called antimetabolites …   English dictionary of cancer terms

  • hydroxyurea — (¦)hīˌdräksēˌ noun Etymology: hydroxy + urea : an antineoplastic drug CH4N2O2 used especially to treat melanoma, chronic myelogenous leukemia, and malignant tumors (as of the ovary or neck) * * * /huy drok see yoo ree euh, yoor ee euh/, n. Pharm …   Useful english dictionary

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