- An enzyme with catalytic activity similar to that of lactoylglutathione lyase, but more general; catalyzes the hydrolysis of an S-2-hydroxyacylglutathione, producing glutathione and a 2-hydroxy acid anion. SEE ALSO: glyoxalase.
* * *hy·droxy·ac·yl·glu·ta·thi·one hy·dro·lase (hi-drok″se-a″səl-gloo″tə-thiґōn hiґdro-lās) [EC 184.108.40.206] an enzyme of the hydrolase class that catalyzes the cleavage of a hydroxyacylglutathione compound to the corresponding hydroxy acid and glutathione, specifically converting lactoylglutathione to lactic acid as the last step in the conversion of methylglyoxal to lactic acid. The enzyme is found in red cells and other animal tissues. See also glyoxalase.
Medical dictionary. 2011.
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glyoxalase — An enzyme, lactoylglutathione lyase (g. I) or hydroxyacylglutathione hydrolase (g. II), in red cells and other tissues that converts glyoxal and substituted glyoxals bound to glutathione into the corresponding free hydroxy acid s (g. II) or… … Medical dictionary