hydroxyacylglutathione hydrolase

An enzyme with catalytic activity similar to that of lactoylglutathione lyase, but more general; catalyzes the hydrolysis of an S-2-hydroxyacylglutathione, producing glutathione and a 2-hydroxy acid anion. SEE ALSO: glyoxalase.

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hy·droxy·ac·yl·glu·ta·thi·one hy·dro·lase (hi-drok″se-a″səl-gloo″tə-thiґōn hiґdro-lās) [EC 3.1.2.6] an enzyme of the hydrolase class that catalyzes the cleavage of a hydroxyacylglutathione compound to the corresponding hydroxy acid and glutathione, specifically converting lactoylglutathione to lactic acid as the last step in the conversion of methylglyoxal to lactic acid. The enzyme is found in red cells and other animal tissues. See also glyoxalase.

Medical dictionary. 2011.

Look at other dictionaries:

  • Hydroxyacylglutathione hydrolase — In enzymology, a Hydroxyacylglutathione hydrolase (EC number|3.1.2.6) is an enzyme that catalyzes the chemical reaction:(R) S lactoylglutathione + water ightleftharpoons glutathione + a 2 hydroxy carboxylateHence, this enzyme has two substrate,… …   Wikipedia

  • hydroxyacylglutathione hydrolase — noun An enzyme involved in pyruvate metabolism …   Wiktionary

  • HAGH — Hydroxyacylglutathione hydrolase, also known as HAGH, is a human gene.cite web | title = Entrez Gene: HAGH hydroxyacylglutathione hydrolase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=3029| accessdate …   Wikipedia

  • List of EC numbers (EC 3) — This list contains a list of EC numbers for the third group, EC 3, hydrolases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 3.1: Acting on Ester BondsEC… …   Wikipedia

  • glyoxalase — An enzyme, lactoylglutathione lyase (g. I) or hydroxyacylglutathione hydrolase (g. II), in red cells and other tissues that converts glyoxal and substituted glyoxals bound to glutathione into the corresponding free hydroxy acid s (g. II) or… …   Medical dictionary

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