Duchenne muscular dystrophy
* * *Duchenne muscular dystrophy also Duchenne's muscular dystrophy n a severe progressive form of muscular dystrophy of males that appears in early childhood, affects the muscles of the legs before those of the arms and the proximal muscles of the limbs before the distal ones, is inherited as an X-linked recessive trait, is characterized by complete absence of the protein dystrophin, and usu. has a fatal outcome by age 20 abbr. DMD see BECKER MUSCULAR DYSTROPHY
* * *Duchenne type muscular dystrophy the most common and severe type of pseudohypertrophic muscular dystrophy; chronic and progressive, it begins in early childhood. It is characterized by increasing weakness in the pelvic and shoulder girdles, with pseudohypertrophy of the muscles followed by atrophy, lordosis, and a peculiar swaying gait with the legs kept wide apart. It is transmitted as an X-linked trait and has been linked to mutations of the gene encoding the protein dystrophin. Affected individuals, predominantly males, rarely survive to maturity; death is usually due to respiratory weakness or heart failure. Called also Duchenne or Duchenne-Griesinger disease, Erb muscular d., and Zimmerlin atrophy. Cf. Becker muscular d.
Duchenne muscular dystrophy. Earlier stage of characteristic and progressive difficulty in rising from the floor, requiring unilateral hand support on the knee.
Medical dictionary. 2011.
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Duchenne muscular dystrophy — Classification and external resources Histopathology of gastrocnemius muscle from patient who died of pseudohypertrophic muscular dystrophy, Duchenne type. Cross section of muscle shows extensive replacement of muscle fibers by adipose cells … Wikipedia
Duchenne muscular dystrophy — [do͞o shen′] n. a common hereditary form of muscular dystrophy, usually affecting young males, characterized by the severe weakening of the skeletal muscles, esp. the respiratory muscles: also called Duchenne s muscular dystrophy * * * … Universalium
Duchenne muscular dystrophy — [do͞o shen′] n. a common hereditary form of muscular dystrophy, usually affecting young males, characterized by the severe weakening of the skeletal muscles, esp. the respiratory muscles: also called Duchenne s muscular dystrophy … English World dictionary
Duchenne muscular dystrophy — noun Etymology: Guillaume Armand Duchenne died 1875 French neurologist Date: 1971 a severe progressive X linked muscular dystrophy of males with early childhood onset that is characterized by absence of the protein dystrophin called also Duchenne … New Collegiate Dictionary
duchenne muscular dystrophy — noun also duchenne s muscular dystrophy Usage: usually capitalized 1st D Etymology: after Guillaume Armand Duchenne died 1875 French neurologist : a severe progressive form of muscular dystrophy of males that appears in early childhood, affects… … Useful english dictionary
Duchenne muscular dystrophy — /duˈʃɛn/ (say dooh shen) noun a type of muscular dystrophy caused by a genetic mutation which prevents production of the protein dystrophin, causing muscles to deteriorate and break down; the most frequently occurring, and one of the most rapidly … Australian English dictionary
Duchenne muscular dystrophy — see muscular dystrophy G. B. A. Duchenne (1806 75), French neurologist … Medical dictionary
Duchenne muscular dystrophy — [du: ʃɛn] noun a severe form of muscular dystrophy caused by a genetic defect and usually affecting boys. Origin C19: named after the French neurologist G. B. A. Duchenne … English new terms dictionary
Duchenne muscular dystrophy — A sex linked hereditary disease confined to young males and to females with Turner s syndrome. It is characterized by degeneration and necrosis of skeletal muscle fibres, that are replaced by fat and fibrous tissue. The incidence of this disorder … Dictionary of molecular biology
Duchenne muscular dystrophy — DMD … The new mediacal dictionary