glucuronosyltransferase

Any of a family of enzymes that transfer d-glucuronate to the acceptor named, forming glucuronosides; e.g., UDPglucuronate-bilirubin g..

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glu·cu·ron·o·syl·trans·fer·ase (gloo″ku-ron″o-səl-transґfər-ās) [EC 2.4.1.17] an enzyme of the transferase class that catalyzes the transfer of a glucuronate moiety from UDP-glucuronate to an acceptor to form a glucuronide conjugate. The reaction occurs with a wide range of substrates and is important in the conversion of bilirubin to its more soluble glucuronide conjugates, which are then secreted into the bile. Deficiency of the enzyme, an autosomal recessive trait, results in Crigler-Najjar syndrome.

Medical dictionary. 2011.

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  • Glucuronosyltransferase — Protein Name=PAGENAME caption= Symbol=UGT1A1 AltSymbols= HGNCid=12530 Chromosome=2 Arm=q Band=37 LocusSupplementaryData= ECnumber=2.4.1.17 OMIM=191740 EntrezGene=54658 RefSeq=NM 000463 UniProt=P22309 PDB=Uridine 5 diphospho… …   Wikipedia

  • glucuronosyltransferase — noun A glycosyltransferase that catalyzes the glucuronidation reaction …   Wiktionary

  • Glucuronosyltransferase, UDP- — A liver enzyme essential to the disposal of bilirubin (the chemical that results from the normal breakdown of hemoglobin from red blood cells). An abnormality of this enzyme (UDP glucuronosyltransferase) results in a condition called Gilbert s… …   Medical dictionary

  • Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase — In enzymology, a galactosylgalactosylxylosylprotein 3 beta glucuronosyltransferase (EC number|2.4.1.135) is an enzyme that catalyzes the chemical reaction:UDP glucuronate + 3 beta D galactosyl 4 beta D galactosyl O beta D xylosylprotein… …   Wikipedia

  • Luteolin-7-O-diglucuronide 4'-O-glucuronosyltransferase — In enzymology, a luteolin 7 O diglucuronide 4 O glucuronosyltransferase (EC number|2.4.1.191) is an enzyme that catalyzes the chemical reaction:UDP glucuronate + luteolin 7 O beta D diglucuronide ightleftharpoons UDP + luteolin 7 O [beta D… …   Wikipedia

  • Luteolin-7-O-glucuronide 2"-O-glucuronosyltransferase — In enzymology, a luteolin 7 O glucuronide 2 O glucuronosyltransferase (EC number|2.4.1.190) is an enzyme that catalyzes the chemical reaction:UDP glucuronate + luteolin 7 O beta D glucuronide ightleftharpoons UDP + luteolin 7 O [beta D… …   Wikipedia

  • Bilirubin-glucuronoside glucuronosyltransferase — In enzymology, a bilirubin glucuronoside glucuronosyltransferase (EC number|2.4.1.95) is an enzyme that catalyzes the chemical reaction:2 bilirubin glucuronoside ightleftharpoons bilirubin + bilirubin bisglucuronosideHence, this enzyme has one… …   Wikipedia

  • Luteolin 7-O-glucuronosyltransferase — In enzymology, a luteolin 7 O glucuronosyltransferase (EC number|2.4.1.189) is an enzyme that catalyzes the chemical reaction:UDP glucuronate + luteolin ightleftharpoons UDP + luteolin 7 O beta D glucuronideThus, the two substrates of this enzyme …   Wikipedia

  • N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase — Identifiers EC number 2.4.1.226 CAS number 269077 98 7 …   Wikipedia

  • N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase — Identifiers EC number 2.4.1.225 CAS number 145539 84 0 …   Wikipedia

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