fructose-bisphosphate aldolase

Fructose-1,6-bisphosphate triophosphate-lyase; an enzyme reversibly cleaving fructose 1,6-bisphosphate to dihydroxyacetone phosphate and glyceraldehyde 3-phosphate; also acts on certain ketose 1-phosphates; deficient in individuals with hereditary fructose intolerance (aldolase B); a deficiency of aldolase A leads to erythrocyte aldolase deficiency with nonspherocytic hemolytic anemia. Cf.:hereditary fructose intolerance. SYN: 1-phosphofructaldolase, fructose-diphosphate aldolase.

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fruc·tose-bis·phos·phate al·do·lase (frookґtōs bis-fosґfāt alґdo-lās) [EC 4.1.2.13] an enzyme of the lyase class that catalyzes the cleavage of fructose 1,6-bisphosphate to form dihydroxyacetone phosphate and glyceraldehyde 3-phosphate, a reaction of the Embden-Meyerhof pathway (see illustration under pathway). The enzyme also catalyzes the conversion of fructose 1-phosphate to dihydroxyacetone phosphate and glyceraldehyde. Three isozymes are recognized: A (occurring primarily in skeletal muscle), B (in liver, kidney, small intestine, and leukocytes), and C (in brain). Isozyme B, often referred to as fructose 1-phosphate aldolase, has greater affinity for fructose 1-phosphate. Deficiency of the latter activity, an autosomal recessive trait, results in hereditary fructose intolerance. Called also aldolase.

Medical dictionary. 2011.

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  • fructose-diphosphate aldolase — SYN: fructose bisphosphate aldolase …   Medical dictionary

  • Aldolase A — is an enzyme which catalyses one of the aldol reactions: The substrate, fructose 1,6 bisphosphate (F 1,6 BP) is broken down into glyceraldehyde 3 phosphate and dihydroxyacetone phosphate (DHAP). This reaction is a part of glycolysis. Three… …   Wikipedia

  • Fructose 6-phosphate — IUPAC name [(2R,3R,4S) 3,4,5 trihydroxy 5 (hydroxymethyl)oxolan 2 yl] metho …   Wikipedia

  • Fructose 1,6-bisphosphate — Chembox new ImageFile=Beta D fructose 1,6 bisphosphate wpmp.png ImageSize=150px IUPACName= OtherNames= Section1= Chembox Identifiers CASNo=488 69 7 PubChem=172313 SMILES=C(C1C(C(C(O1)(COP(=O)(O)O)O)O)O)OP(=O)(O)O MeSHName=fructose 1,6 diphosphate …   Wikipedia

  • aldolase — 1. Generic term for aldehyde lyase. 2. Name sometimes applied to fructose bisphosphate a.. * * * al·dol·ase al də .lās, .lāz n a crystalline enzyme that occurs widely in living systems and catalyzes reversibly the cleavage of a fructose ester… …   Medical dictionary

  • fructose 1-phosphate aldolase — fruc·tose 1 phos·phate al·do·lase (frookґtōs fosґfāt alґdo lās) fructose bisphosphate aldolase, isozyme B …   Medical dictionary

  • Aldolase B — is an isoenzyme of fructose 1,6 bisphosphate aldolase (aldolase A), which is also capable of cleaving fructose 1 phosphate to form glyceraldehyde and dihydroxyacetone phosphate (DHAP). The reaction is reversible. Also known as Aldolase (Class II) …   Wikipedia

  • Aldolase — Fructose diphosphate aldolase A   N° EC …   Wikipédia en Français

  • Fructose-1,6-diphosphate — β D fructose 1,6 diphosphate         …   Wikipédia en Français

  • ketose-1-phosphate aldolase — Fructose bisphosphate aldolase …   Medical dictionary


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