floxuridine

The deoxynucleoside of fluorouracil; an antineoplastic agent. Fluorouracil is metabolized to f. and this, in turn, to 5-fluoro-2′-deoxyuridine 5′-monophosphate. The latter agent inhibits thymidylic synthetase; uridine phosphatase is also inhibited.

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flox·uri·dine (floks-ūrґĭ-dēn) [USP] a fluoropyrimidine that is metabolically activated to the monophosphate nucleotide (F-dUMP), the metabolite of 5-fluorouracil (q.v.) that blocks DNA synthesis; FUDR is also metabolized to 5-fluorouracil; it is used as an antineoplastic by intra-arterial administration for treatment of liver metastases from gastrointestinal malignancies.

Medical dictionary. 2011.

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