Fc

See F. fragment.
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family coping; fasciculus cuneatus; fast component [of a neuron]; febrile convulsions; feline conjunctivitis; ferric chloride; ferric citrate; fibrocyte; finger clubbing; finger counting; flow compensation; fluorescein conjugated; fluorocarbon; fluorocytosine; fold change; Foley catheter; follicle culture; foster care; fowl cholera; free cholesterol; frontal cortex; functional castration

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[fragment, crystallizable] originally, the fragment, not containing antigen combining sites, obtained by papain cleavage of the IgG molecule; now generally used as an adjective, e.g., Fc region, segment, to refer to the part of any immunoglobulin monomer comprising the hinge region and CH2, CH3, and CH4 domains of both heavy chains. The Fc region contains the allotypic markers and mediates all biologic activities including complement activation, binding to cell-surface receptors (Fc receptors, IgE receptors), and transplacental transport of IgG. Cf. Fab.

Medical dictionary. 2011.

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