deoxyribonuclease

Any enzyme (phosphodiesterase) hydrolyzing phosphodiester bonds in DNA. SEE ALSO: endonuclease, nuclease.
- acid d. SYN: d. II.
- d. I, DNase I an endonuclease that cleaves primarily double-stranded DNA to a mixture of oligodeoxyribonucleotides, each ending in a 5′-phosphate; streptodornase is a similar enzyme. Under appropriate conditions, it can produce single-strand nicks in DNA; used in nick translation and in the mapping of hypersensitive sites. SYN: pancreatic d., thymonuclease.
- d. II, DNase II an endonuclease that cleaves both strands of native DNA (as well as single-stranded DNA) to produce a mixture of oligodeoxynucleotides, each ending in a 3′-phosphate. SYN: acid d..
- pancreatic d. SYN: d. I.
- d. S1 SYN: endonuclease S1 Aspergillus.
- spleen d. former name for micrococcal endonuclease.

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de·oxy·ri·bo·nu·cle·ase (')dē-'äk-si-.rī-bō-'n(y)ü-klē-.ās, -.āz also des·oxy·ri·bo·nu·cle·ase (')des- n an enzyme that hydrolyzes DNA to nucleotides called also DNase

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n.
an enzyme, located in the lysosome of cells, that splits DNA at specific places in the molecule.

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de·oxy·ri·bo·nu·cle·ase (DNase) (de-ok″se-ri″bo-nooґkle-ās) any nuclease specifically catalyzing the cleavage of phosphate ester linkages in deoxyribonucleic acids; the deoxyribonucleases are grouped as those cleaving internal bonds (endodeoxyribonucleases) and those cleaving at termini (exodeoxyribonucleases).

Medical dictionary. 2011.

Look at other dictionaries:

  • Deoxyribonuclease I — Identifiers Symbols DNASE1; DKFZp686H0155; DNL1; DRNI; FLJ38093; FLJ44902 External IDs …   Wikipedia

  • Deoxyribonuclease II — alpha Identifiers Symbol DNASE2 Alt. symbols DNASE2A, DRN2, DNL, DNL2 Entrez 1777 …   Wikipedia

  • Deoxyribonuclease IV — is a type of deoxyribonuclease that functions at AP sites. See also phage T4 External links MeSH Deoxyriboendonuclease+IV EC 3.1.21.2 Lindahl T, Gally JA, Edelman GM (1969). Deoxyribonuclease I …   Wikipedia

  • deoxyribonuclease — deoxyribonuclease. См. ДНК аза. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • Deoxyribonuclease — Crystals of DNase protein. A deoxyribonuclease (DNase, for short) is any enzyme that catalyzes the hydrolytic cleavage of phosphodiester linkages in the DNA backbone. Thus, deoxyribonucleases are one type of nuclease. A wide variety of… …   Wikipedia

  • deoxyribonuclease — deoksiribonukleazė statusas T sritis chemija apibrėžtis Fermentas, skaidantis DNR. santrumpa( os) DNR azė atitikmenys: angl. deoxyribonuclease rus. дезоксирибонуклеаза …   Chemijos terminų aiškinamasis žodynas

  • deoxyribonuclease — noun Date: 1946 DNase …   New Collegiate Dictionary

  • deoxyribonuclease — (= DNAase; DNase) An endonucleasewith preference for DNA. Pancreatic DNAase I yields di and oligo nucleotide 5&’ phosphates, pancreatic DNAase II yields 3&’ phosphates. In chromatin, the sensitivity of DNA to digestion by DNAase I depends on its… …   Dictionary of molecular biology

  • deoxyribonuclease — /dee ok si ruy boh nooh klee ays , ayz , nyooh /, n. Biochem. See DNase. [1945 50; DEOXY + RIBONUCLEASE] * * * …   Universalium

  • deoxyribonuclease — noun Any of several enzymes that catalyze the cleavage of DNA. Syn: DNase …   Wiktionary

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