* * *cy·clo·ox·y·gen·ase .sī-klō-'äk-si-jə-.nās, -äk-'sij-ə-, -.nāz n an enzyme that catalyzes the conversion of arachidonic acid to prostaglandins, that is inactivated by aspirin and other NSAIDs, and that has two isoforms of which one is involved in the cascade of events producing the pain and inflammation of arthritis and the other is not see COX-1, COX-2
* * *cy·clo·oxy·gen·ase (COX) (si″klo-okґsə-jən-ās) an activity of prostaglandin-endoperoxide synthase (q.v.). There are two isoforms, called cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). COX-1 is involved in the synthesis of prostaglandins that maintain the integrity of the gastrointestinal mucosa. COX-2 is made primarily in response to injury or inflammation and is involved in the synthesis of prostaglandins involved in inflammation and the immune response. See also COX-2 inhibitor, under inhibitor.
Medical dictionary. 2011.
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Cyclooxygenase — COX redirects here. For other meanings, see Cox (disambiguation). prostaglandin endoperoxide synthase Identifiers EC number 220.127.116.11 CAS number … Wikipedia
cyclooxygenase — noun either of two related enzymes that control the production of prostaglandins and are blocked by aspirin • Syn: ↑Cox • Hypernyms: ↑enzyme • Hyponyms: ↑cyclooxygenase 1, ↑Cox 1, ↑cyclooxygenase 2, ↑C … Useful english dictionary
cyclooxygenase-1 — noun an enzyme that regulates prostaglandins that are important for the health of the stomach lining and kidneys an unfortunate side effect of NSAIDs is that they block Cox 1 • Syn: ↑Cox 1 • Hypernyms: ↑cyclooxygenase, ↑Cox … Useful english dictionary
cyclooxygenase-2 — noun an enzyme that makes prostaglandins that cause inflammation and pain and fever the beneficial effects of NSAIDs result from their ability to block Cox 2 • Syn: ↑Cox 2 • Hypernyms: ↑cyclooxygenase, ↑Cox … Useful english dictionary
cyclooxygenase — noun Etymology: cycl + oxygenase, an enzyme, from oxygen + ase Date: 1975 an enzyme that catalyzes the conversion of arachidonic acid to prostaglandins and that has two isoforms of which one is involved in the creation of prostaglandins which… … New Collegiate Dictionary
cyclooxygenase — noun Any of several enzymes that catalyze the conversion of arachidonic acid into prostaglandins; their inhibition is the mode of action of aspirin and ibuprofen … Wiktionary