clathrin

The principal constituent of a polyhedral protein lattice that coats eukaryotic cell membranes (vesicles) and coated pits and appears to be involved in protein secretion. This protein also occurs in synaptic vesicles. [L. clathri, lattice]

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clath·rin 'klath-rin n the major component protein of a cagelike polyhedral molecular arrangement that forms on the cytoplasmic side of a cell's plasma membrane and coats the endocytotic vesicles which bud off from the membrane

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clath·rin (klathґrin) a protein consisting of three limbs, each composed of a heavy (180 kD) and a light (about 35 kD) chain, in a triskelion arrangement; it coats the cytoplasmic face of coated pits (q.v.) in receptor-mediated endocytosis. Clathrin-coated vesicles are also involved in retrieval of synaptic vesicle membrane following neurotransmitter release and in vesicle formation on the trans-Golgi network and endosomes. The coat depolymerizes after the vesicle buds from the membrane and the clathrin units are reused.

Medical dictionary. 2011.

Look at other dictionaries:

  • Clathrin — clathrin, light polypeptide (Lca) Identifiers Symbol CLTA Entrez 1211 HUGO …   Wikipedia

  • Clathrin — coat Clathrin ist ein Protein, das an der Einstülpung von Zellmembranen und der Bildung von Vesikeln beteiligt ist (vor allem bei der rezeptorabhängigen Endozytose). Nach dem Abschnüren wird das Clathrin der Stachelsaumbläschen (Clathrin coated… …   Deutsch Wikipedia

  • clathrin — clathrin. См. клатрин. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • clathrin — Protein composed of 3 heavy chains (180 kD) and 3 light chains (34 and 36 kD), that forms the basketwork of triskelions around a coated vesicle. There are two genes for light chains, each of which can generate two distinct transcripts by tissue… …   Dictionary of molecular biology

  • clathrin — /klath rin/, n. Cell Biol. a basketlike network of protein molecules that forms on the cell membrane in response to the attachment of ligands to receptors and becomes the inside surface of the coated vesicle during endocytosis. [prob. CLATHR(ATE) …   Universalium

  • clathrin — noun A fibrous protein that forms a polyhedral coat on the surface of the coated pits and vesicles of cells during endocytosis …   Wiktionary

  • clathrin — /klath rin/, n. Cell Biol. a basketlike network of protein molecules that forms on the cell membrane in response to the attachment of ligands to receptors and becomes the inside surface of the coated vesicle during endocytosis. [prob. CLATHR(ATE) …   Useful english dictionary

  • Clathrin-independent carrier — Clathrin independent carriers (CLICs) are prevalent tubulovesicular membranes responsible for non clathrin mediated endocytic events. They appear to endocytose material into GEECs. Collectively, CLICs and GEECs comprise the CLIC/GEEC endocytic… …   Wikipedia

  • clathrin adaptor proteins — (= HA1 and HA2 adaptors) Family of proteins that bind to clathrin and promote its assembly into vesicle coats. Different adaptor proteins are associated with coated vesicles of Golgi or plasma membrane origin …   Dictionary of molecular biology

  • clathrin-coated vesicle — a transport vesicle having a clathrin coat, involved in the transport of products from the Golgi complex to lysosomes, the transport of molecules taken up by endocytosis, and the retrieval of synaptic vesicle membrane following neurotransmitter… …   Medical dictionary

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