cisplatin

A chemotherapeutic agent with antitumor activity; c. binds DNA and interferes with DNA synthesis; strongly emetogenic.

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cis·plat·in 'sis-.plat-ən n a platinum-containing antineoplastic drug Cl2H6N2Pt that functions as an alkylating agent, produces crosslinks in DNA between and within strands, and is used esp. as a palliative therapy in testicular and ovarian tumors and in advanced bladder cancer see PLATINOL

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n.
a heavy-metal compound: a cytotoxic drug that impedes cell division by damaging DNA. Administered intravenously, it is important in the treatment of testicular and ovarian tumours. It is highly toxic; side-effects include nausea, vomiting, kidney damage, peripheral neuropathy, and hearing loss. Less toxic analogue of cisplatin are now available (see carboplatin).

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cis·plat·in (sisґplat-in) [USP] cis-diamminedichloroplatinum, a platinum coordination complex capable of producing inter- and intrastrand DNA crosslinks and having a broad spectrum of antitumor activity, used in the treatment of a wide variety of neoplasms, particularly metastatic ovarian and testicular carcinoma and advanced carcinoma of the bladder; administered intravenously. Called also CDDP, cis-DDP, and DDP.

Medical dictionary. 2011.

Look at other dictionaries:

  • Cisplatin — Systematic (IUPAC) name (SP 4 2) diamminedichloridoplatinum …   Wikipedia

  • cisplatin — cisplatin. См. цисплатин. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • cisplatin — [sis plat′ n] n. [ CIS + PLATIN(UM)] a white, powdery drug, PtCl2H6N2, containing platinum, used to stop the growth of cancerous tumors, esp. in the ovary, testis, or bladder …   English World dictionary

  • Cisplatin — Strukturformel Allgemeines Freiname Cisplatin Andere Namen …   Deutsch Wikipedia

  • cisplatin — n. a platinum containing compound: a cytotoxic drug that impedes cell division by damaging DNA. Administered intravenously, it is used in the treatment of various cancers, including testicular tumours and cancers of the head and neck. It is… …   The new mediacal dictionary

  • cisplatin — noun Etymology: cis + platinum Date: 1977 a platinum containing antineoplastic drug Cl2H6N2Pt used especially in the treatment of testicular and ovarian tumors and advanced bladder cancer …   New Collegiate Dictionary

  • cisplatin — (= cis diammineplatinum dichloride) Cytotoxic drug used in tumour chemotherapy. Binds to DNA and forms platinum nitrogen bonds with adjacent guanines …   Dictionary of molecular biology

  • cisplatin — /sis plat n/, n. Pharm. a platinum containing white powder, PtCl2H6N2, used to treat ovarian carcinoma and other cancers. Also, cisplatinum /sis plat n euhm, plat neuhm/. [1975 80; CIS + PLATIN(UM)] * * * …   Universalium

  • cisplatin — noun A simple organic compound of platinum, cis diamminedichloroplatinum(II), that is used as a chemotherapy agent against several types of cancer. Syn: CDDP, cisplatinum, Platinol AQ …   Wiktionary

  • Cisplatin — Cịs|pla|tin [↑ cis u. ↑ Platin], das; s: internat. Freiname für einen cytostatisch wirksamen, wenn auch toxischen Platin Komplex (↑ Peyrone Salz) …   Universal-Lexikon

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