neurofibrillary tangles

intracellular knots or clumps of neurofibrils seen in the cerebral cortex in Alzheimer disease.

Neurofibrillary tangle within neuronal cytoplasm (silver stain).


Medical dictionary. 2011.

Look at other dictionaries:

  • neurofibrillary tangles — /ˌnjuroʊˌfɪbrɪləri ˈtæŋgəlz/ (say .nyoohroh.fibriluhree tangguhlz) plural noun an accumulation of twisted protein fragments inside a nerve cell, as in a brain cell affected by Alzheimer s disease. Also, tangles …   Australian English dictionary

  • Neurofibrillary tangle — Microscopy image of a neurofibrillary tangle, conformed by hyperphosphorylated tau protein Neurofibrillary Tangles (NFTs) are aggregates of hyperphosphorylated tau protein that are most commonly known as a primary marker of Alzheimer s Disease.… …   Wikipedia

  • neurofibrillary tangle — A characteristic pathological feature of the brain of patients with Alzheimer&’s disease is the presence of tangles of coarse neurofibrils within large neurons of the cerebral cortex. Whether this causes neuronal degeneration or is a secondary… …   Dictionary of molecular biology

  • Alzheimer neurofibrillary degeneration — neurofibrillary tangles …   Medical dictionary

  • Нейрофибриллярные узлы — (neurofibrillary tangles) переплетенные протеиновые волокна, формирующиеся внутри некоторых клеток мозга, когда люди стареют …   Общая психология: глоссарий

  • Alzheimer's disease — Alzheimer redirects here. For other uses, see Alzheimer (disambiguation). Alzheimer s disease Classification and external resources …   Wikipedia

  • Alzheimer disease — Degenerative brain disorder. It occurs in middle to late adult life, destroying neurons and connections in the cerebral cortex and resulting in significant loss of brain mass. The most common form of dementia, Alzheimer disease progresses from… …   Universalium

  • Memory disorder — Memory can be defined as an organism s ability to encode, retain, and recall information. Disorders of memory can range from mild to severe, yet are all a result of damage to neuroanatomical structures; either in part or in full. This damage… …   Wikipedia

  • Biochemistry of Alzheimer's disease — The biochemistry of Alzheimer s disease (AD), one of the most common causes of adult dementia, is as yet not well understood at the molecular level. It has been identified as a protein misfolding disease due to the accumulation of abnormally… …   Wikipedia

  • Tauopathy — Infobox Disease Name = PAGENAME Caption = DiseasesDB = ICD10 = ICD9 = ICDO = OMIM = MedlinePlus = eMedicineSubj = eMedicineTopic = MeshID = D024801 Tauopathies are a class of neurodegenerative diseases resulting from the pathological aggregation… …   Wikipedia


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